|Table of Contents|

Analysis of clinical significance of phosphofructokinase in lung cancer based on online database

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
48-52
Research Field:
Publishing date:

Info

Title:
Analysis of clinical significance of phosphofructokinase in lung cancer based on online database
Author(s):
Zheng Chunlei1; 2; Wang Yizhe3; Liu Yunpeng1; 2; Bao Bowen1; 2; Lu Wenqing1; 2; Hu Xuejun3; Che Xiaofang1; 2
1.Department of Medical Oncology；3.Department of Respiratory and Infectious Disease of Geriatrics，the First Hospital of China Medical University,Liaoning Shenyang 110001,China；2.Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province,Liaoning Shenyang 110001,China.
Keywords:
lung cancer; phosphofructokinase; The Cancer Genome Atlas; prognosis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.01.012
Abstract:
Objective：To investigate the prognostic value of different subtypes of phosphofructokinase 1(PFK1) and predict the possible biological processes related to PFKP in lung carcinoma.Methods：The expression value and clinical data of different subtypes of PFK1(PFKP/PFKL/PFKM) were downloaded from The Cancer Genome Atlas(TCGA) database.The correlation of each subtypes of PFK1 expression with the clinicopathological parameters and survival time of patients was analyzed.Gene Set Enrichment Analysis(GSEA) was used to predict the crucial pathway in high PFKP expression patients.Results：PFKP expression levels were associated with tumor infiltration depth(T stage)，number of metastatic lymph node(N stage) and gender.The overall survival(OS) of lung cancer patients with higher expression of PFKP was shorter than that with low expression(P<0.05).The gene sets，such as glycolysis and gluconeogenesis，adheren junction，cell cycle pathway，were enriched in the samples with high expression of PFKP.Conclusion：High expression of PFKP is a poor prognostic factor for lung cancer，and PFKP can be used as a potential prognosis prediction biomarker for lung cancer.

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Memo

Memo:
National Natural Science Foundation of China(No.81472193）；国家自然科学基金面上项目(编号：81472193)；辽宁省中央引导地方科技发展专项资金(编号：2016007010)；辽宁省重点研发指导计划项目(编号：2018225060)
Last Update: 1900-01-01