|Table of Contents|

The expression of HOXC6 in nasopharyngeal carcinoma and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
43-48
Research Field:
Publishing date:

Info

Title:
The expression of HOXC6 in nasopharyngeal carcinoma and its clinical significance
Author(s):
Zhang Zhenyu; Zhang Xiuping
Department of Radiotherapy，the Affiliated Cancer Hospital of Guangzhou Medical University，Guangdong Guangzhou 510095，China.
Keywords:
HOXC6; nasopharyngeal carcinoma; clinical prognosis; immunohistochemistry; GEO database
PACS:
R739.63
DOI:
10.3969/j.issn.1672-4992.2020.01.011
Abstract:
Objective：To explore the expression of HOXC6 in nasopharyngeal carcinoma and its clinical significance.Methods：Immunohistochemistry was used to detect the expression of HOXC6 protein in 127 cases of paraffin tissue specimens from patients with nasopharyngeal carcinoma.The correlation between the expression of HOXC6 protein and clinical data was analyzed.The nasopharyngeal carcinoma gene chip datasets GSE12452 and GSE13597 were downloaded from the GEO public database to analyze the differential expression of HOXC6 gene at the transcriptional level between nasopharyngeal carcinoma and normal nasopharyngeal tissues.Further explore the possible mechanism of action of HOXC6 gene in nasopharyngeal carcinoma by GSEA analysis method.Results：The level of HOXC6 expression was significantly correlated with the T stage，N stage and clinical stage of nasopharyngeal carcinoma (P<0.05).COX multivariate analysis showed that N stage(P=0.022) and HOXC6 expression level(P=0.038) were independent risk factors for the prognosis of patients with nasopharyngeal carcinoma.GSEA analysis indicated that HOXC6 gene high expression samples were mainly enriched in apoptosis，TNF-α signaling，IL6/JAK/STAT3 signaling pathway.Conclusion：HOXC6 gene is associated with development in nasopharyngeal carcinoma and its high expression might be an independent prognostic risk factor.

References:

［1］Chua Melvin LK，Wee Joseph TS，Hui EP，et al.Nasopharyngeal carcinoma［J］.Lancet，2016，387(10022)：1012-1024.
［2］Sun X，Su S，Chen C，et al.Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma：An analysis of survival and treatment toxicities［J］.Radiotherapy and Oncology，2014，110(3)：398-403.
［3］Lee A，Ng W，Chan Y，et al.The battle against nasopharyngeal cancer［J］.Radiotherapy & Oncology Journal of the European Society for Therapeutic Radiology & Oncology，2012，104(3)：272-278.
［4］Joo MK，Park J，Chun HJ，et al.Impact of homeobox genes in gastrointestinal cancer［J］.World Journal of Gastroenterology，2016，22(37)：8247-8256.
［5］Northcott JM，Northey JJ，Barnes JM，et al.Fighting the force：Potential of homeobox genes for tumor microenvironment regulation［J］.Biochimica et Biophysica Acta(BBA)-Reviews on Cancer，2015，1855(2)：248-253.
［6］Rodrigues MF，Esteves CM，Xavier FC，et al.Methylation status of homeobox genes in common human cancers［J］.Genomics，2016，108(5)：185-193.
［7］Ansari KI，Hussain I，Shrestha B，et al.HOXC6 is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment［J］.Journal of Molecular Biology，2011，411(2)：334-349.
［8］Shen LY，Fan MY，Dong B，et al.Increased HOXC6 expression predicts chemotherapy sensitivity in patients with esophageal squamous cell carcinoma［J］.Oncology Letters，2017，14(4)：4835-4840.
［9］Chen SW，Zhang Q，Xu ZF，et al.HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9［J］.Molecular Medicine Reports，2016，14(4)：3261.
［10］Li PD，Chen P，Peng X，et al.HOXC6 predicts invasion and poor survival in hepatocellular carcinoma by driving epithelial-mesenchymal transition［J］.Aging，2018，10(1)：115-130.
［11］Zhang Q，Jin XS，Yang ZY，et al.Upregulated Hoxc6 expression is associated with poor survival in gastric cancer patients［J］.Neoplasma，2013，60(4)：439-445.
［12］Cotter，Thomas G.Apoptosis and cancer：the genesis of a research field［J］.Nature Reviews Cancer，2009，9(7)：501-507.
［13］Mullard，Asher.Pioneering apoptosis-targeted cancer drug poised for FDA approval［J］.Nature Reviews Drug Discovery，2016，15(4)：292.
［14］Moon SM，Kim SA，Yoon JH，et al.HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression［J］.Journal of Biological Chemistry，2012，287(42)：35678.
［15］Ramachandran S，Liu P，Young AN，et al.Loss of HOXC6 expression induces apoptosis in prostate cancer cells［J］.Oncogene，2005，24(1)：188-198.
［16］Johnson DE，O' Keefe RA，Grandis JR.Targeting the IL-6/JAK/STAT3 signalling axis in cancer［J］.Nature Reviews Clinical Oncology，2018，15(4)：234.
［17］Zhang Z，Lin G，Yan Y，et al.Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells［J］.Oncogene，2018，37(25).doi:10.1038/s41388-018-0221-4.

Memo

Memo:
吴阶平医学基金会临床科研专项资助基金（编号：320.6750.17112）
Last Update: 1900-01-01