|Table of Contents|

FoxM1-regulatory network:Anticancer new target

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1059-1063
Research Field:
Publishing date:

Info

Title:
FoxM1-regulatory network:Anticancer new target
Author(s):
Shi Jiaqi; Liu Chao; Zhang Yanqiao
Department of Digestive Internal Medicine Second Ward,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
FoxM1; cancer; protein interactions; anticancer drugs
PACS:
R730.53
DOI:
10.3969/j.issn.1672-4992.2019.06.038
Abstract:
Forkhead box protein M1 (FoxM1) is a transcription factor of the Forkhead family involved in the cell proliferation.However,studies have shown that FoxM1 is overexpressed in a variety of human cancers and associated with the major hallmarks of cancer described by Hanahan and Weinberg.It has been postulated that the oncogenic potential of FoxM1 depends on its capacity to transactivate target genes.In addition,FoxM1 can also play an oncogenic role by inducing Wnt and transforming growth factor-β (TGF-β) signaling pathways,respectively,through interacting with other proteins such as β-catenin or mothers against decapentaplegic homolog 3 (SMAD3).In this review,we will discuss the protein-protein interactions of FoxM1 that are critical for cancer development and may represent novel targets for anticancer drugs.

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Memo

Memo:
National Natural Science Foundation of China(No.81672428);国家自然科学基金面上项目（编号：81672428）；北京希思科临床肿瘤学研究基金（编号：Y-MX2016-027）
Last Update: 1900-01-01