|Table of Contents|

Effect of combination of Toad capsule and TN chemotherapy on serum levels of SCC and TSGF and quality of life in patients with advanced cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1052-1057
Research Field:
Publishing date:

Info

Title:
Effect of combination of Toad capsule and TN chemotherapy on serum levels of SCC and TSGF and quality of life in patients with advanced cervical cancer
Author(s):
Li Qian1Liu Chunyan1Cui Jian2
1.Department of Gynaecology and Obstetrics,Chinese and Japanese Hospital,Beijing 100029,China;2.Department of Gynaecology and Obstetrics,Xinjiang Production and Construction Corps Hospital,Xinjiang Urumqi 830002,China.
Keywords:
cervical cancermiddle-later stageToad capsuleTN chemotherapy schemeserum SCCTSGFquality of life
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2019.06.036
Abstract:
Objective:To explore the application value of combination of Toad capsule and TN chemotherapy in treating patients with advanced cervical cancer.Methods:71 cases of advanced cervical cancer with radiotherapy were selected and divided into groups according to random numbers.35 cases in the control group were treated with TN chemotherapy,and 36 cases in the observation group were treated with TN chemotherapy+Toad capsule.The clinical effects and the levels of serum squamous cell carcinoma related antigen (SCC),tumor specific growth factor (TSGF) and the each dimension score of quality of life before and after the treatment of the two groups were compared.The incidence of adverse reactions and the 1-year,2-year,and 3-year survival rates of the two groups were also statistically analyzed.Results:The clinical remission rate in the observation group was 83.33%(30/36),higher than that in the control group 57.14%(20/35)(P<0.05).After 4 courses of treatment,the levels of serum SCC and TSGF in the observation group were lower than those in the control group(P<0.05).The incidence of constipation,diarrhea and nausea and vomiting in the observation group was not significantly different from that in the control group(P>0.05).The incidence of leukocyte decline in the observation group was 11.11%(4/36),lower than that in the control group 31.43%(11/35) (P<0.05).After 4 courses of treatment,the scores of cognition,role,body,society,and emotion of quality of life in the observation group were higher than those in the control group(P<0.05).The 1-year survival rate of the observation group was 91.67%(33/36),the 2-year survival rate was 86.11%(31/36) and the 3-year survival rate was 77.78%(28/36).The difference was not statistically significant compared with the control group (91.43%,85.71%,74.29%)(P>0.05).Conclusion:TN chemotherapy combined with Toad capsule can reduce the levels of serum TSGF and SCC in advanced cervical cancer patients with radiotherapy,and improve the quality of survival.It is effective and safe.

References:

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