|Table of Contents|

The differential value of 18FDG PET/CT to N2 mediastinal lymph nodes in NSCLC

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1039-1043
Research Field:
Publishing date:

Info

Title:
The differential value of 18FDG PET/CT to N2 mediastinal lymph nodes in NSCLC
Author(s):
Li Hong; Li Guangjun; Guo Xingfu; Li Xiang; Shao Wenyu; Qin Xudong; Liu Shuangling
Department of Nuclear Medicine,Northeast International Hospital,Liaoning Shenyang 110623,China.
Keywords:
non-small cell lung cancer; lymph node metastasis; 18FDG; PET/CT
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.06.033
Abstract:
Objective:To evaluate the diagnostic value of 18FDG PET/CT in assessing the involvement of central mediastinal lymph nodes (N2) in NSCLC.Methods:Seventy-two NSCLC patients with 280 stations of mediastinal lymph nodes were dissected.We respectively analyzed the diagnosis of N2 lymph nodes by preoperative CT and 18FDG PET/CT with pathological diagnosis.Results:One-hundred seventy-five stations of N2 lymph nodes were diagnosed metastasis by CT and 172 stations by 18FDG PET/CT scan.The sensitivity,specificity,accuracy,positive and negative predictive value of CT and PET/CT were 74.0% vs 89.0%,50% vs 68.7%,62.5% vs 79.3%,61.7% vs 75.6% and 63.8% vs 85.2%,respectively.PET/CT scan showed significantly higher diagnosis performance than CT scan (P＜0.05).Of 105 recorded <10 mm N2 lymph nodes 36.2%(38/105) was positive by pathology,and the sensitivity,specificity,accuracy,positive and negative predictive value by 18FDG PET/CT scan were 86.8%,88.1%,87.6%,80.5% and 92.2%,respectively.While,the high 18FDG uptake of <10 mm N2 lymph nodes were located to stations 2R,4R/L and 7,which were 36.4%(12/33),27.3%(9/33) and 36.4%(12/33),respectively.Conclusion:18FDG PET/CT scan is more sensitive and accurate than CT in diagnosis of N2 lymph nodes,especially for evaluation of <10 mm mediastinal lymph nodes.

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