|Table of Contents|

Expression of perilipin-1 gene in primary retroperitoneal liposarcoma and its correlation with the therapeutic effect of apatinib

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1031-1035
Research Field:
Publishing date:

Info

Title:
Expression of perilipin-1 gene in primary retroperitoneal liposarcoma and its correlation with the therapeutic effect of apatinib
Author(s):
Meng Lingxin1; Li Bingcheng1; Meng Qin1; Zheng Yuxiu1; Ding Zhaojun1; Xu Meiling1; Sun Shuyan2
1.Oncology Department;2.Pathology Department,Rizhao City People's Hospital,Shandong Rizhao 276826,China.
Keywords:
liposarcoma; perilipin(PLIN); apatinib; soft tissue sarcoma
PACS:
R730.262
DOI:
10.3969/j.issn.1672-4992.2019.06.031
Abstract:
Objective:To investigate the expression of the gene protein perilipin-1(PLIN1) in primary retroperitoneal liposarcoma and its correlation with the therapeutic effect of apatinib.Methods:36 cases of primary retroperitoneal liposarcoma and 20 cases of lipoma were detected by immunohistochemical SABC.The relationship was analyzed between the therapeutic efficacy of PLIN1 protein and apatinib.Results:PLIN1 protein expressed 19.44%(7/36) positive rate and 70.00%(14/20) positive rate in primary retroperitoneal liposarcoma and lipoma respectively,and the positive rate was significantly different in the tissues (P＜0.05).PLIN1 protein had no correlation with age,gender and tumor size of the patient.Patients with low expression of PLIN1 protein had better efficacy than patients with high expression group in the oral treatment of apatinib,and the expression of PLIN1 protein in primary retroperitoneal liposarcoma was negatively correlated with the efficacy (P＜0.05).Conclusion:PLIN1 protein is related to the development and differentiation of primary retroperitoneal liposarcoma.It can be used as one of the reference indicators to determine the degree of differentiation and malignant degree of primary retroperitoneal liposarcoma,but it has nothing to do with the recurrence of tumors.PLIN1 protein expression can be used as a biological reference target for the targeted treatment of apatinib.

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Memo:
山东省医药卫生科技发展计划项目（编号：2016WS0329）
Last Update: 1900-01-01