|Table of Contents|

Polymorphism in STAT3 SNP and its association with biological behavior of colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1028-1031
Research Field:
Publishing date:

Info

Title:
Polymorphism in STAT3 SNP and its association with biological behavior of colorectal cancer
Author(s):
Sun Yongchen1; Chen Zhigang2
1.Department of Oncology,Shangqiu First People's Hospital,Henan Shangqiu 476100,China；2.Department of Oncology,the Second Affiliated Hospital of Soochow University,Jiangsu Suzhou 215006,China.
Keywords:
STAT3; SNP; colorectal cancer; tumor biological behavior
PACS:
R735.3+5；R735.3+7
DOI:
10.3969/j.issn.1672-4992.2019.06.030
Abstract:
Objective:To examine the relationship between signal transducer and activators of transcription 3(STAT3) SNP (rs4796793) and biological behaviors in colorectal cancer.Methods:Genotyping of rs4796793 was carried out by single-tube SYBR GREEN PCR with Tm-shift primers.Genotypes were analyzed in 118 colorectal cancer patients by SPSS 16.0.Results:Stratified analysis indicated that an elevated risk of vessel/nerve invasion was observed in patients who carried at least G allele (CG or GG) compared with CC genotype (P=0.009) and also a significant difference was found in alleles between C and G(P=0.001).Conclusion:Among these pathological parameters concerned,STAT3 SNP was associated with vessel/nerve invasion.G allele indicates high risk of vessel/nerve invasion.

References:

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Memo

Memo:
苏州市科教兴卫基金（编号：KJXW2013017）
Last Update: 1900-01-01