|Table of Contents|

Correlation analysis of bacterial microbiota between the tongue coating and the soil in the patients with precancerous lesions of upper digestive tract

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
1009-1016
Research Field:
Publishing date:

Info

Title:
Correlation analysis of bacterial microbiota between the tongue coating and the soil in the patients with precancerous lesions of upper digestive tract
Author(s):
Sun Xian1Xu Jing1Hua Zhaolai2Cheng Ying1Lu Bin3Zhan Zhen1Zhang Junfeng1
1.School of Medicine and Life Sciences,Nanjing University of Chinese Medicine,Jiangsu Nanjing 210023,China;2.Yangzhong Cancer Institute,Jiangsu Yangzhong 212200,China;3.Department of Oncology,People's Hospital of Yangzhong City,Jiangsu Yangzhong 212200,China.
Keywords:
precancerous lesions of upper digestive tracttongue coatingprivate plotssoilmicrobiota
PACS:
R735
DOI:
10.3969/j.issn.1672-4992.2019.06.026
Abstract:
Objective:To investigate the correlation of bacterial microbiota between the soil and the tongue coating in patients with precancerous lesions of upper digestive tract (PLUDT) in Yangzhong.Methods:Twenty-two patients with PLUDT were recruited,and the tongue coating samples and soil samples from their private plots were collected at the same time.The bacterial microbiota were measured by high throughput sequencing based on V3-V5 16S rRNA gene.Bioinformatics analysis was conducted to present the alpha-diversity,beta-diversity,community structure,symbiotic relationship.Results:The bacterial richness and diversity in the tongue coating were distinctly lower than that in the soil,and their bacterial communities were significantly different.Spearman correlation analysis showed that seventeen taxa (one phylum,two classes,three orders,three families,four genera and four species) were significantly correlated between the tongue coating and the soil.Based on the predicted function of the bacterial microbiota,four predicted functions (the lipid transport and metabolism,post-translational modification,protein turnover,chaperones,single transduction mechanisms and defense mechanisms) were negatively correlated,and one predicted function (the intracellular trafficking,secretion,and vesicular transport) was positively correlated.Conclusion:The bacterial microbiota in the tongue coating from the patients with PLUDT was related with that in the soil,and the bacterial microbiota in the soil may play a key role in the high incidence of upper gastrointestinal carcinoma in Yangzhong.

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Memo

Memo:
National Natural Science Foundation of China(No.81473458,81473593);国家自然科学基金(编号:81473458,81473593);镇江市重点研发计划(编号:SH2016024)
Last Update: 1900-01-01