|Table of Contents|

Effect and mechanism of aquaporin AQP4 on proliferation of breast cancer cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
943-946
Research Field:
Publishing date:

Info

Title:
Effect and mechanism of aquaporin AQP4 on proliferation of breast cancer cells
Author(s):
Li Yingbin1; Sun Shengrong2
1.Inner Mongolia People's Hospital,Inner Mongolia Hohhot 010017,China；2.Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China.
Keywords:
aquaporin 4; small interfering RNA; proliferation; pathway
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2019.06.009
Abstract:
Objective:To study the expression of AQP4 in human breast cancer cells,and further explore the effect and mechanism of AQP4 on the proliferation of tumor cells.Methods：Down regulation of aquaporin 4 expression in breast cancer cell lines T47D and MCF-7 was performed by siRNA interference technology.The effect of this downregulation on the proliferation of breast cancer cells was detected and its mechanism was explored.Results：The decrease of AQP4 expression inhibited the proliferation of breast cancer cells.It may be realized through the E-calcium/ERK pathway.Conclusion：AQP4 expression level is positively related to the proliferation of breast cancer cells.The corresponding tumor inhibitors can play a role in controlling tumor growth.

References:

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Memo

Memo:
内蒙古自治区人民医院院内基金（编号：2016032）
Last Update: 1900-01-01