|Table of Contents|

Study of side population cells and related pathways in acute leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 06
Page:
914-919
Research Field:
Publishing date:

Info

Title:
Study of side population cells and related pathways in acute leukemia
Author(s):
Wang LeiLi Yan
The First Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
ABC transporterABCG2PTENPI3K/AKTside population cells
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2019.06.003
Abstract:
Objective:To understand the significance of SP cells in the pathogenesis of acute leukemia.Methods:SP and MP cells of acute leukemia cell lines were isolated by Hoechst 33342 staining.The biological characteristics of SP and MP cells were compared and the changes of related pathways were studied.Results:SP cells could be separated from the acute leukemia cell line,and a higher G1 phase expression was found,also higher cell proliferation and cloning ability,and high expression of ABCG2 resistant protein,and stronger chemotherapeutic resistance.Conclusion:Acute leukemia SP cells have the biological characteristics of tumor stem cells,ABCG2 may be used as a marker of the surface of acute leukemia SP cells.

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Memo

Memo:
National Natural Science Foundation of China(No.81600117);国家自然科学基金资助项目(编号:81600117)
Last Update: 1900-01-01