|Table of Contents|

Progression of the research on PD-1/PD-L1 in dMMR/MSI-H colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
885-888
Research Field:
Publishing date:

Info

Title:
Progression of the research on PD-1/PD-L1 in dMMR/MSI-H colorectal cancer
Author(s):
Xie TongtongHu JingYang MiLi LiLiu BaoruiQian Xiaoping
The Comprehensive Cancer Center,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Jiangsu Nanjing 210008,China.
Keywords:
colorectal cancerimmunotherapyPD-1PD-L1
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2019.05.042
Abstract:
At present,colorectal cancer is one of the common tumors,and PD-1/PD-L1 immunotherapy for dMMR/MSI-H colorectal cancer is a hot spot.Some clinical trials have achieved good results.In 2017,NCCN guide recommends nivolumab and pembrolizumab as the drug choice for the second or third line of dMMR/MSI-H metastatic colorectal cancer.In this paper,the present study on the characteristics of dMMR/MSI-H colorectal cancer,the biological function of PD-1/PD-L1,the treatment of PD-1/PD-L1 in CRC and the serious adverse reactions in the research process were reviewed.

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Memo

Memo:
江苏省自然科学基金(编号:BK20161107);江苏省卫计委发展项目(编号:H2017042);南京市科技发展计划项目(编号:201503013)
Last Update: 2019-02-01