|Table of Contents|

Research progress of animal models of lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
873-878
Research Field:
Publishing date:

Info

Title:
Research progress of animal models of lung cancer
Author(s):
Dong Changsheng12Bi Ling3Que Zujun1Tian Jianhui12
1.Tumor Institute of Traditional Chinese Medicine Affiliated to Shanghai Academy of Traditional Chinese Medicine and Pharmacology,Shanghai 200032,China;2.Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;3.Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China.
Keywords:
lung canceranimal modelPDTX
PACS:
R73-35.4
DOI:
10.3969/j.issn.1672-4992.2019.05.040
Abstract:
Lack of a suitable prevention and treatment animal model of lung cancer is a major obstacle for basic research and drug development.The existing xenotrans-planted subcutaneous tumor model cannot reflect the actual role in the pathogenes is of lung cancer and the incidence of lung cancer and actual pathological process on microenvironment.Orthotopic transplant tumor model can solve the above problems,because it can fully embodies the characteristics of lung cancer biology.Combined with the small animal in vivo imaging technology can objectively evaluate dynamic changes in lung tumor burden and the actual metastasis,it will be the main direction of the development of an animal model of lung cancer in future.Patient derived tumor xenograft(PDTX) and organ like models can also partially reflect the heterogeneity of tumor microenvironment and tumor cells,which have become an important trend in this field.

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Memo

Memo:
National Natural Science Foundation of China(No.81403356,81774166);国家自然科学基金(编号:81403356,81774166);上海市卫计委市级医疗卫生优秀学科带头人培养计划资助项目(编号:2017BR044);上海市卫计委科研课题面上项目(编号:201640178);杏林中青年人才(杏林青年学者)培养项目(编号:RC-2017-02-02)
Last Update: 2019-02-01