|Table of Contents|

Research progress of immune checkpoint LAG-3 in tumor immunotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
870-873
Research Field:
Publishing date:

Info

Title:
Research progress of immune checkpoint LAG-3 in tumor immunotherapy
Author(s):
Hu XiaoruYang Xianghong
Department of Pathology,China Medical Univercity Affiliated Shengjing Hospital,Liaoning Shenyang 110004,China.
Keywords:
immune checkpointLAG-3tumorimmunotherapy
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2019.05.039
Abstract:
Immune checkpoint inhibition,as a kind of adequately studied immunotherapy,is based on the blocking of passing inhibiting signals,excitation the CTL and inducing T lymphocyte to produce anti-tumor effect.LAG-3 is a kind of inhibitory molecule with multiple biological effects which is fond as a member of the immune checkpoint family.It has a high expression in the tumor infiltrating lymphocytes of many kinds of tumor tissues performing the tumor immune escape.Thus,we can conclude that LAG-3 will act as an important indicator in the prognosis and therapy of tumor.This review will talk about the expression and function of LAG-3 in tumor and how it is used in therapy.

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Memo

Memo:
National Natural Science Foundation of China(No.81773108);国家自然科学基金资助项目(编号:81773108)
Last Update: 2019-02-01