|Table of Contents|

A primary study of the volume CT perfusion in predicting treatment response in patients with cervical squamous carcinoma treated with chemotherapy and radiation therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
859-864
Research Field:
Publishing date:

Info

Title:
A primary study of the volume CT perfusion in predicting treatment response in patients with cervical squamous carcinoma treated with chemotherapy and radiation therapy
Author(s):
Dong RuitongDong YueLuo YahongHu QiyunWang FeifeiYu Tao
Department of Medical Imaging,Cancer Hospital of Chinese Medical University,Liaoning Shenyang 110042,China.
Keywords:
cervical squamous carcinoma(CSC)computed tomographyvolume perfusionchemotherapy and radiatio therapy(CRT)
PACS:
R730.4
DOI:
10.3969/j.issn.1672-4992.2019.05.036
Abstract:
Objective:To assess the application value of volume CT perfusion(vCTP) in predicting the efficacy of chemotherapy and radiatio therapy(CRT) treatment in patients with cervical squamous carcinoma(CSC).Methods:22 patients with histology proven CSC were enrolled in the study.All patients underwent a whole-uterus vCTP on a 640-slice CT system within one week before CRT,and reconducted a routine contrast-enhanced CT after the treatment.The patients were divided into different groups according to the response evalution criteria in solid tumours(RECIST).The data including patients' general informations,CSC artery flow(AF),blood volume(BV) and permeability surface(PS),external iliac artery AF of different groups were compared to explore the clinical index and CTP parameters which can predict the treatment efficacy.Differences were tested using t test or Fisher exact test.The CTP parameters with significant differences between different groups were further analysed by receiver operating characteristic(ROC) curve to assess the efficacy in predicting the treatment result of CRT for CSC.Results:After CRT,15 cases were divided into complete response(CR) group,and 7 cases were in partial response(PR) group.There was no significant differences in patients' age,BMI,FIGO stage,pathological grade,maximum diameter and maximum area before treatment between the two groups(P>0.05).The AF of CSC and external iliac artery in CR group were significantly higher than those in PR group(P<0.05).However no significant differences were found in BV and PS between the two groups(P>0.05).ROC curve analysis revealed that the corresponding AUC of the AF of CSC and external iliac artery to predict the efficacy of CRT for CSC were 0.829,0.876 respectively.Conclusion:The parameters AF of vCTP are helpful to predict the response of CSC patients after CRT.

References:

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沈阳市科学技术计划项目(编号:F16-206-9-23)
Last Update: 2019-02-01