|Table of Contents|

Expression and significance of tumor specific growth factor and tumor infiltrating dendritic cells in patients with endometrial carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
845-848
Research Field:
Publishing date:

Info

Title:
Expression and significance of tumor specific growth factor and tumor infiltrating dendritic cells in patients with endometrial carcinoma
Author(s):
Yan QiaohuiXing GuochenPan Qiong
Department of Oncology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Henan Zhengzhou 450007,China.
Keywords:
tumor specific growth factortumor infiltrating dendritic cellendometrial carcinomalymphatic metastasis
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2019.05.032
Abstract:
Objective:To investigate the expression and significance of tumor specific growth factor(TSFG) and tumor infiltrating dendritic cell(TIDC) in patients with endometrial carcinoma.Methods:From January 2015 to January 2017,we prospectively collected 50 patients with endometrial carcinoma in our hospital.The levels of TIDC in endometrial tissues and serum TSFG were detected,and the correlation between TSFG,TIDC and clinical features of the patients was analyzed.Results:When compared with adjacent tissues,tumor tissues got a reduced TIDC(P=0.000),a lower percentage of MHC-Ⅱ positive DC(%)(P=0.000),and a reduce in CD54 positive DC(%)(P=0.000).When compared with patients without lymph node metastasis,TIDC,MHC-Ⅱ positive DC(%),CD54 positive DC(%) in patients with lymph node metastasis were significantly lower,and TSFG increased significantly(P<0.05).When compared with patients with Ⅰ or Ⅱ of TNM stage,TIDC,MHC-Ⅱ positive DC(%) and CD54 positive DC(%) decreased significantly in patients with stage Ⅲ or Ⅳ,and TSFG increased significantly(P<0.05).When compared with the myometrial invasion ≤1/2 patients,TIDC,MHC-Ⅱ positive DC(%) and CD54 positive DC(%) were significantly decreased in myometrial invasion >1/2 patients,TSFG significantly increased(P<0.05).When compared with patients with moderate and high differentiated patients,TIDC,MHC-Ⅱ positive DC(%) and CD54 positive DC(%) were significantly decreased in poorly differentiated,and TSFG increased significatly(P<0.05).Conclusion:The expression of TIDC in tumor tissues is low,and most of them are immature regulatory DC cells.In the patients with poorly differentiated,stage Ⅲ or Ⅳ,lymph node metastasis,the level of serum TSFG in patients with myometrial infiltration >1/2 were increased significantly,and TIDC were decreased significantly.The results suggest that serum TSFG and TIDC in tumor tissue can be used as prognostic indicators.

References:

[1]Felix AS,Yang HP,Bell DW,et al.Epidemiology of endometrial carcinoma:Etiologic importance of hormonal and metabolic influences[J].Adv Exp Med Biol,2017,943(12):3-46.
[2]Brasky TM,Felix AS,Cohn DE,et al.Nonsteroidal anti-inflammatory drugs and endometrial carcinoma mortality and recurrence[J].J Natl Cancer Inst,2017,109(3):1-10.
[3]Bjorner S,Rosendahl AH,Simonsson M,et al.Combined and individual tumor-specific expression of insulin-like growth factor-I receptor,insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer:Implications for prognosis in different treatment groups[J].Oncotarget,2017,8(6):9093-9107.
[4]Warnders FJ,Terwisscha van Scheltinga AGT,Knuehl C,et al.Human epidermal growth factor receptor 3-specific tumor uptake and biodistribution of 89Zr-MSB0010853 visualized by real-time and noninvasive PET imaging[J].J Nucl Med,2017,58(8):1210-1215.
[5]Zhang W,Ding Y,Zhang C,et al.Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor[J].Oncogene,2017,36(30):4277-4287.
[6]Shurin GV,Ma Y,Shurin MR.Immunosuppressive mechanisms of regulatory dendritic cells in cancer[J].Cancer Microenviron,2013,6(2):159-167.
[7]Huang XM,Liu XS,Lin XK,et al.Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer[J].Cancer Sci,2014,105(2):150-158.
[8]Lijun Z,Xin Z,Danhua S,et al.Tumor-infiltrating dendritic cells may be used as clinicopathologic prognostic factors in endometrial carcinoma[J].Int J Gynecol Cancer,2012,22(5):836-841.
[9]Liu Y,Tian JW,Xu Y,et al.Role of transvaginal contrast-enhanced ultrasound in the early diagnosis of endometrial carcinoma[J].Chin Med J(Engl),2012,125(3):416-421.
[10]Austin RM.George papanicolaou's efforts to develop novel cytologic methods for the early diagnosis of endometrial carcinoma[J].Acta Cytol,2017,61(4-5):281-298.
[11]Smith LE,Olszewski MA,Georgoudaki AM,et al.Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions[J].J Leukoc Biol,2016,100(4):781-789.
[12]Yan J,Liu B,Shi Y,et al.Class Ⅱ MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo[J].J Exp Med,2017,214(2):319-326.
[13]Spallanzani RG,Torres NI,Avila DE,et al.Regulatory dendritic cells restrain NK cell IFN-gamma production through mechanisms involving NKp46,IL-10,and MHC class I-Specific inhibitory receptors[J].J Immunol,2015,195(5):2141-2148.
[14]Chen J,Guo XZ,Li HY,et al.Dendritic cells engineered to secrete anti-DcR3 antibody augment cytotoxic T lymphocyte response against pancreatic cancer in vitro[J].World J Gastroenterol,2017,23(5):817-829.
[15]Zhou J,Ma P,Li J,et al.Comparative analysis of cytotoxic T lymphocyte response induced by dendritic cells pulsed with recombinant adeno-associated virus carrying alpha-fetoprotein gene or cancer cell lysate[J].Mol Med Rep,2015,11(4):3174-3180.
[16]Lin CL,Hsiao G,Wang CC,et al.Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells[J].Pharmacol Res,2016,110(20):111-121.
[17]Gueguen C,Bouley J,Moussu H,et al.Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy[J].J Allergy Clin Immunol,2016,137(2):545-558.
[18]Yu S,Zou G,Wei Q.Ultrasensitive electrochemical immunosensor for quantitative detection of tumor specific growth factor by using Ag@CeO2 nanocomposite as labels[J].Talanta,2016,156(157):11-17.
[19]Wang P,Zhu J,Xie XL,et al.Effects on the tumor specific growth factor and tumor necrosis factor alpha in rats' precancerous lesion of primary hepatocellular carcinoma by direct moxibustion at Ganshu(BL 18) acupoint[J].Chin J Integr Med,2016,22(7):532-536.
[20]Xi Chenhui,He Bing,Cheng Zhijian.Clinical significance of determination of TSGF and HPA levels in diagnosis of hashimoto's thyroiditis complicated with thyroid papillary carcinoma[J].Modern Journal of Integrated Chinese and Western Medicine,2016,25(12):1315-1317.[席晨辉,何秉,程志俭.Gal-3、TSGF和HPA水平检测诊断桥本甲状腺炎合并甲状腺乳头状癌的临床意义[J].现代中西医结合杂志,2016,25(12):1315-1317.]

Memo

Memo:
河南省科技厅科技计划项目(编号:2017-0321)
Last Update: 2019-02-01