|Table of Contents|

The expression and clinical significance of PGRMC1 in endometrial carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
839-844
Research Field:
Publishing date:

Info

Title:
The expression and clinical significance of PGRMC1 in endometrial carcinoma
Author(s):
Liu Miao; Qi Yue; Tan Mingzi; Jin Shan; Liu Juanjuan; Ye Qiulin; Li Xiao; Liu Qing; Hao Yingying; Lin Bei
Department of Gynecology and Obstetrics，Shengjing Hospital Affiliated to China Medical University，Liaoning Shenyang 110004，China．
Keywords:
endometrial carcinoma; PGRMC1; immunohistochemistry; clinicopathological parameters
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2019.05.031
Abstract:
Objective：To explore the relationship between expression of PGRMC1 and clinicopathological parameters，prognosis and the clinical significance of PGRMC1 by detecting the expression of PGRMC1 in different endometrial tissues.Methods：Expression of PGRMC1 in endometrial carcinoma，atypical hyperplasia endometrium，normal endometrium was detected by immunohistochemistry，and the relationship between PGRMC1 expression and clinicopathological parameters in endometrial carcinoma was analyzed.Results：The expression level of PGRMC1 in endometrial carcinoma（98.61%) was significantly higher than atypical hyperplasia and normal endometrium（62.07%，4.17%)（both P<0.05).The strong positive rate of PGRMCl in type Ⅰ was significantly higher than type Ⅱ（P<0.05).In endometrial carcinoma，the increase of PGRMC1 was detected in those with positive ER and PR status.However，the expression of PGRMC1 had no relationship with FIGO stage，pathological grades，vascular invasion and lymph node metastasis.The survival curve analysis showed that the overall prognosis of patients with endometrial carcinoma was unrelated to the expression of PGRMC1，but in clear cell endometrial carcinoma，strong positive expression of PGRMC1 could predict a poor prognosis，P<0.05.Follow the Cox regression model analysis，late FIGO stage，vascular invasion ≥1/2 could be the risk factors associated with the prognosis of endometrial carcinoma（P<0.05).Conclusion：The expression level of PGRMC1 was significantly increased in endometrial carcinoma，it is associated with the development of the endometrial carcinoma.The strong positive expression of PGRMC1 was associated with the type of endometrial carcinoma and status of ER，PR.Strong positive expression of PGRMC1 could predict a poor prognosis in clear cell endometrial carcinoma.

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Last Update: 2019-02-01