|Table of Contents|

Value of serum PSA and fPSA/tPSA in the diagnosis of bone metastasis from prostate cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
836-839
Research Field:
Publishing date:

Info

Title:
Value of serum PSA and fPSA/tPSA in the diagnosis of bone metastasis from prostate cancer
Author(s):
Zhou JianpingZhang XinliWang ChunmeiSong XiaolongYang Ru
Department of Radio Immunity Center,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China.
Keywords:
electrochemiluminescenceprostate specific antigenratioprostatic carcinomabone metastasis
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2019.05.030
Abstract:
Objective:To evaluate the value of serum PSA and fPSA/tPSA in the diagnosis of bone metastasis from prostate cancer by analyzing the relationship between bone metastasis with serum PSA and fPSA/tPSA in prostate cancer patients.Methods:Serum fPSA and tPSA of 74 cases of patients with prostate cancer were measured by automatic electrochemiluminescence analyzer and fPSA/tPSA ratio was calculated.Systemic bone scan imaging was performed for all prostate cancer patients.Results:Of the 74 cases of prostate cancer,29 patients had no bone metastasis,45 of them had bone metastases,accounting for 39.2% and 60.8% of prostate cancer patients respectively.There were 5 cases of single lesion in prostate cancer patients with bone metastasis,accounting for 11.1%,3 of them in pelvis and 2 in vertebral body.There were 3 cases of metastases at two,which accounted for 6.7%.37 cases,or 82.2%,were three metastases or more.From the site of bone metastasis,there were 35 cases of vertebral metastases.There were 31 cases of pelvic metastases.There were 28 cases of rib metastases,9 of the four limbs were transferred,and 2 were transferred from other parts.Serum PSA and fPSA/tPSA of bone metastasis group and non-bone metastasis group in prostate cancer were respectively:(57.68±38.67) ng/ml,0.14±0.08,(21.61±17.87) ng/ml,0.25±0.09,the difference was statistically significant(P<0.05).Conclusion:The bone metastasis from prostate cancer is mainly focused on multiple lesions,and the lesion mainly occurs in the spine and pelvis.The incidence of bone metastasis increased with going up of serum PSA concentration or going down of fPSA/tPSA.When PSA>20.00 ng/ml or fPSA/tPSA≤0.15,the sensitivity and specificity of diagnosis bone metastasis from prostate cancer are higher.

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Last Update: 2019-02-01