|Table of Contents|

Effects of bilirubin and aminotransferase levels on the survival of patients with primary gastric cancer after surgical treatment

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
830-833
Research Field:
Publishing date:

Info

Title:
Effects of bilirubin and aminotransferase levels on the survival of patients with primary gastric cancer after surgical treatment
Author(s):
Zhang Fei; Lv Chuanxin; Ye Xiaoyong
Department of General Surgery，Liuhe Hospital Affiliated to Medical College of Yangzhou University，Jiangsu Nanjing 211500，China.
Keywords:
bilirubin; aminotransferase; primary gastric cancer; surgical treatment; survival status
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.05.028
Abstract:
Objective：To investigate the effects of bilirubin and aminotransferase levels on the survival of patients with primary gastric cancer after surgical treatment.Methods：A total of 312 patients with gastric cancer were enrolled in our hospital from January 2013 to December 2015.116 patients died as the death group and 196 survivors as survival group.Diazo the bilirubin level was measured by the method and the aminotransferase level was measured by the rate method.Results：The levels of TBIL，DBIL，and IBIL in the death group［（21.04±4.02) μmol/L，(5.30±1.03) μmol/L，(16.38±1.44) μmol/L］ were significantly higher than those in the survival group［（14.39±4.95) μmol/L，(3.55±1.04) μmol/L，（10.20±3.58) μmol/L］，with statistically significant differences（P<0.05)，AST and ALT levels in the death group［（69.38±14.56) U/L，(113.85±14.73) U/L］ were significantly higher than those in the survival group［（21.84±10.83) U/L，(24.59±10.34) U/L］，with statistically significant differences（P<0.05).Most of the clinical stages were stage Ⅱ and Ⅲ.The infiltration depth was mostly T3 and T4.The lymph node metastasis rate and distant metastasis rate were significantly higher than those in the survival group.The statistical difference was significant（P<0.05).Logistic regression showed that DBIL and AST levels were independent risk factors for survival after treatment in gastric cancer patients(P<0.05).Conclusion：The levels of DBIL and AST are negatively correlated with the survival of patients with gastric cancer.The elevated DBIL and AST levels are independent risk factors for the survival of patients with gastric cancer after treatment.

References:

[1]Li JJ，Liu BZ，Yin HH，et al.Clinical significance of preoperative bilirubin and aminotransferase levels in the prognosis of gastric cancer［J］.Journal of Huazhong University of Science and Technology(Health Sciences)，2016，45(5)：504-508.［李军杰，刘斌正，阴慧慧，等.术前胆红素及氨基转移酶水平在胃癌预后中的临床意义［J］.华中科技大学学报（医学版），2016，45(5)：504-508.］
[2]Hu X，Chen ZY.Clinical characteristics and prognosis of patients with liver metastases from gastric cancer［J］.Bulletin of Medical Postgraduate，2017，30(2)：169-172.［胡晓，陈子洋.胃癌肝转移患者的临床特征及预后生存分析［J］.医学研究生学报，2017，30(2)：169-172.］
[3]Sun FY，Li JY，Han CW.Analysis of factors influencing prognosis of patients with radical gastrectomy after gastric cancer［J］.Chinese Journal of Clinic（Earth)，2016，10(7)：139-140.［孙凤永，李继福，韩春伟.胃癌根治术后患者预后的影响因素分析［J］.中华临床医师杂志（电子版），2016，10(7)：139-140.］
[4]Sun LL，Jin YL，Liu GH，et al.Neonatal cerebrospinal fluid bilirubin in the diagnosis of bilirubin encephalopathy［J］.Zhonghua General Hospital，2013，11(8)：1181-1183.［孙路璐，金玉莲，刘光辉，等.新生儿脑脊液胆红素在胆红素脑病诊断中的研究［J］.中华全科医学，2013，11(8)：1181-1183.］
[5]Yang W，Wang X，Liu KY，et al.Correlation between serum aminotransferase levels and prognosis of patients with chronic heart failure［J］.Journal of Clinical Amacia，2016，31(3)：332-333.［杨威，王霞，刘凯元，等.血清氨基转移酶水平与慢性心力衰竭患者预后的相关性［J］.临床荟萃，2016，31(3)：332-333.］
[6]Zhao R，Li XH，Cheng ZP，et al.Relationship between serum bilirubin levels and coronary artery lesions［J］.Anhui Medicine，2014，35(1)：12-15.［赵韧，李小虎，程自平，等.血清胆红素水平与冠脉病变的关系［J］.安徽医学，2014，35(1)：12-15.］
[7]Liu HD，Wang P，Kan YF，et al.Analysis of long-term survival and prognostic factors in patients with gastric cancer after radical resection［J］.Modern Digestive and Interventional Diagnosis and Treatment，2016，21(5)：730-733.［刘会东，王鹏，阚永丰，等.胃癌根治术后患者远期生存情况及预后影响因素分析［J］.现代消化及介入诊疗，2016，21(5)：730-733.］
[8]Lin JY.Research progress in bilirubin metabolism and its regulation［J］.Fudan Journal（Medical Sciences)，2014，41(3)：405-411.［林佳媛.胆红素代谢及其调节的研究进展［J］.复旦学报（医学版），2014，41(3)：405-411.］
[9]Zhao EH，Ling TL，Cao H.Current status of surgical treatment of gastric cancer in the era of minimally invasive surgery in China：Opportunity and challenge［J］.International Journal of Surgery，2016，28（4）：45-50.
[10]Zhang YP，Wei J，Yang Y，et al.Multivariate analysis of prognosis of advanced gastric cancer［J］.Chinese Journal of Clinical Oncology，2014，19(6)：524-529.［张亚萍，魏嘉，杨阳，等.影响进展期胃癌预后的多因素分析［J］.临床肿瘤学杂志，2014，19(6)：524-529.］
[11]Bger C，Behrens H，Rcken C.Ki67-An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity［J］.Journal of Surgical Oncology，2016，113（1)：46-54.
[12]Sun D，Xu HM，Huang JY.Analysis of prognostic factors of gastric cancer with negative lymph node metastasis［J］.Chinese Journal of Gastrointestinal Surgery，2017，20（2)：190-194.［孙丁，徐惠绵，黄锦宇.淋巴结转移阴性胃癌的预后影响因素分析［J］.中华胃肠外科杂志，2017，20（2)：190-194.］
[13]Rd P，Ridefel P，Aldrimer M，et al.Population-based pediatric reference intervals for HbA1c，bilirubin，albumin，CRP，myoglobin and serum enzymes［J］.The Scandinavian Journal of Clinical and Laboratory Investigation，2013，73(5)：361-367.
[14]Wei TT，Wang LL，Yin JR，et al.Relationship between red blood cell distribution width，bilirubin，and clinical characteristics of patients with gastric cancer［J］.Int J Lab Hem,2017，39(5)：497-501.

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Last Update: 2019-02-01