|Table of Contents|

Clinical value of intensity-modulated radiotherapy for unresectable gastric cancer in elder patients who received palliative care

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
813-816
Research Field:
Publishing date:

Info

Title:
Clinical value of intensity-modulated radiotherapy for unresectable gastric cancer in elder patients who received palliative care
Author(s):
Tian Xiaodong; Shao Ying; Tang Xiaoying; Wang Lei; Zhang Lang; Li Gang; Cai Kai
Department of Radiotherapy，Cancer Center of Pizhou Dongda Hospital，Jiangsu Pizhou 221300，China.
Keywords:
stomach neoplasms; aged; radiotherapy; palliative care; intensity-modulated
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.05.024
Abstract:
Objective：To study the clinical value of intensity-modulated radiotherapy(IMRT) for unresectable gastric cancer in elder patients who received palliative care.Methods：We retrospectively reviewd 23 elder unresectable gastric cancer by pathological diagnosis who received palliative care for key index symptoms of bleeding (78.3%)，obstruction(52.2%)，and pain(69.6%).Study endpoints included symptom reponse，duration of response，and median overall survival（mOS）.Results：The study group included 16 males，7 female，average 74 years old(60~89).Nine cases were stage Ⅲ and 14 cases were stage Ⅳ.All patients were treated by IMRT using 6 MV X-rays conventional fractionation，1.8~2.2 Gy/fraction，5 fractions/week，total doses(biologically effective dose) 35~50 Gy.Five cases received concurrent chemotherapy and 9 cases received subsequent chemotherapy.Symptom reponse rates for bleeding，obstruction，and pain were 77.8%(14/18)，58.3%(7/12)，and 56.2%(9/16)，respectively，and median duration of response was 101 days，87 days，and 99 days，respectively.Median survival was 114 days.Median survival was significantly longer in patients who responded to radiotherapy compared with patients who did not（129 vs 73 days，P=0.01）.Two patients had grade Ⅲ toxicity.Conclusion：IMRT is an effective and well tolerated modality relieving the clinical symptoms for unresectable gastric cancer in elder patients who received palliative care，with improving patient quality of life and prolonging survival.

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Last Update: 2019-02-01