|Table of Contents|

Relationship between preoperative PaO2，PaCO2，PT，Fg，APTT and postoperative pulmonary embolism in gastrointestinal cancer and the occurrence time of pulmonary embolism

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
805-808
Research Field:
Publishing date:

Info

Title:
Relationship between preoperative PaO2，PaCO2，PT，Fg，APTT and postoperative pulmonary embolism in gastrointestinal cancer and the occurrence time of pulmonary embolism
Author(s):
Zou Shihui; Xu Huimian; Huang Baojun
Department of Surgical Oncology，First Affiliated Hospital of China Medical University，Liaoning Shenyang 110000，China.
Keywords:
pulmonary embolism; gastrointestinal cancer surgery; postoperative time
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.05.022
Abstract:
Objective：To explore the relationship between preoperative arterial partial pressure of oxygen(PaO2)，arterial partial pressure of carbon dioxide(PaCO2)，prothrombin time(PT)，fibrinogen(Fg)，active partial thromboplastin time(APTT) and postoperative pulmonary embolism(PE) in gastrointestinal cancer and the occurrence time of pulmonary embolism.Methods：We retrospectively analyzed PE after gastrointestinal cancer surgery from 2004 to 2017 in our hospital.Totally 337 patients were included，31 of 337 patients were diagnosed as PE after surgery.Results：The patients who had lower value of APTT before surgery had a higher risk of getting PE after gastrointestinal cancer surgery(OR：0.80，95%CI：0.64~0.99，P=0.044).The patients who had lower value of PaO2 before operation had higher incidence of getting PE after gastrointestinal cancer operation(OR：0.93，95%CI：0.88~0.99，P=0.018).In addition，the occurrence of PE was concentrated between the 6th day and 9th day.Conclusion：The peak period of PE after gastrointestinal cancer operation is about a week.The decrease value of APTT and PaO2 before operation were all interacted with the progress in PE after gastrointestinal cancer surgery.

References:

［1］Desciak MC，Martin DE.Perioperative pulmonary embolism：Diagnosis and anesthetic management［J］.J Clin Anesthesia，2011，23(2)：153-165.
［2］Weekes AJ，Johnson AK，Troha D，et al.Prognostic value of right ventricular dysfunction markers for serious adverse events in acute normotensive pulmonary embolism［J］.J Emerg Med，2017，52(2)：137-150.
［3］Tanabe Y，Obayashi T，Yamamoto T，et al.Predictive value of biomarkers for the prognosis of acute pulmonary embolism in Japanese patients：Results of the Tokyo CCU Network registry［J］.J Cardiol，2015，66(6)：460-465.
［4］Turetz M，Sideris AT，Friedman OA，et al.Epidemiology，Pathophysiology，and Natural History of Pulmonary Embolism［J］.Semin Intervent Radiol，2018，35(2)：92-98.
［5］Borohovitz A，Weinberg MD，Weinberg I.Pulmonary embolism：Care standards in 2018［J］.Prog Cardiovasc Dis，2018，60(6)：613-621.
［6］Hemon F，Fouchard F，Tromeur C，et al.Association between hospitalization for acute medical illness and VTE risk：A lower efficacy of thromboprophylaxis in elderly patients? Results from the EDITH case-control study［J］.Eur J Intern Med，2017，44：39-43.
［7］Tapson VF.Acute pulmonary embolism［J］.N Engl J Med，2008，358(10)：1037-1052.
［8］Cohen AT，Agnelli G，Anderson FA，et al.Venous thromboembolism (VTE) in Europe.The number of VTE events and associated morbidity and mortality［J］.Thromb Haemost，2007，98(4)：756-764.
［9］Schneider D，Lilienfeld DE，Im W.The epidemiology of pulmonary embolism：Racial contrasts in incidence and in-hospital case fatality［J］.J Natl Med Assoc，2006，98(12)：1967-1972.
［10］Liao S，Woulfe T，Hyder S，et al.Incidence of venous thromboembolism in different ethnic groups：A regional direct comparison study［J］.J Thromb Haemost，2014，12(2)：214-219.
［11］Lee S，Jeong H，In K，et al.Clinical characteristics of acute pulmonary thromboembolism in Korea［J］.Int J Cardiol，2006，108(1)：84-88.
［12］Heit JA，Silverstein MD，Mohr DN，et al.Risk factors for deep vein thrombosis and pulmonary embolism：A population-based case-control study［J］.Arch Intern Med，2000，160(6)：809-815.
［13］Heit JA，O' Fallon WM，Petterson TM，et al.Relative impact of risk factors for deep vein thrombosis and pulmonary embolism：A population-based study［J］.Arch Intern Med，2002，162(11)：1245-1248.
［14］Laporte S，Mismetti P，Decousus H，et al.Clinical predictors for fatal pulmonary embolism in 15 520 patients with venous thromboembolism：Findings from the registro informatizado de la enfermedad tromboembolica venosa(RIETE) registry［J］.Circulation，2008，117(13)：1711-1716.
［15］Aujesky D，Hughes R，Jimenez D.Short-term prognosis of pulmonary embolism［J］.J Thromb Haemost，2009，7(Suppl 1)：318-321.
［16］Temgoua MN，Tochie JN，Noubiap JJ，et al.Global incidence and case fatality rate of pulmonary embolism following major surgery：A protocol for a systematic review and Meta-analysis of cohort studies［J］.Syst Rev，2017，6(1)：240.
［17］Smeltz AM，Kolarczyk LM，Isaak RS.Update on perioperative pulmonary embolism management［J］.Advances in Anesthesia，2017，35(1)：213-228.
［18］Timp JF，Braekkan SK，Versteeg HH，et al.Epidemiology of cancer-associated venous thrombosis［J］.Blood，2013，122(10)：1712-1723.
［19］Sakon M，Maehara Y，Yoshikawa H，et al.Incidence of venous thromboembolism following major abdominal surgery：A multi-center，prospective epidemiological study in Japan［J］.J Thromb Haemost,2006，4(3)：581-586.
［20］Agarwal S，Clark D.Gender disparities in outcomes and resource utilization for acute pulmonary embolism hospitalizations in the united states［J］.Am J Cardiol，2015，116(8)：1270-1276.
［21］Barrios D，Morillo R，Guerassimova I，et al.Sex differences in the characteristics and short-term prognosis of patients presenting with acute symptomatic pulmonary embolism［J］.PLoS One，2017，12(11)：e0187648.
［22］Obradovic S，Dzudovic B，Rusovic S，et al.Gender-related differences in clinical presentation，electrocardiography signs，laboratory markers and outcome in patients with acute pulmonary embolism［J］.Vojnosanit Pregl，2016，73(9)：844-849.
［23］Zalutskii IV，Kasiuk AA，Prudyvus IS.Risk of fatal postoperative pulmonary embolism in cancer patients［J］.Vopr Onkol，2011，57(4)：454-457.
［24］Arachchillage DRJ，Kamani F，Deplano S，et al.Should we abandon the APTT for monitoring unfractionated heparin［J］?Thromb Res，2017，157：157-161.
［25］Bates SM，Weitz JI.Coagulation assays［J］.Circulation，2005，112(4)：e53-60.
［26］Day TK.Blood gas analysis［J］.Vet Clin North Am Small Anim Pract，2002，32(5)：1031-1048.

Memo

Memo:
National Natural Science Foundation of China（No.81272716）;国家自然科学基金（编号：81272716）；沈阳市科学技术计划项目（编号：17-231-1-49）
Last Update: 2019-02-01