|Table of Contents|

Safety and efficacy of gefitinib combined with pemetrexed and cisplatin in the treatment of advanced non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 05
Page:
796-800
Research Field:
Publishing date:

Info

Title:
Safety and efficacy of gefitinib combined with pemetrexed and cisplatin in the treatment of advanced non-small cell lung cancer
Author(s):
Guo HaoZhou ShuniRan Ruizhi
Enshi Tujia and Miao Autonomous Prefecture Central Hospital,Hubei Enshi 445000,China.
Keywords:
gefitinibpemetrexedcisplatinnon-small cell lung cancer
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.05.020
Abstract:
Objective:To observe the efficacy of pemetrexed and cisplatin in combination with gefitinib as second-line treatment in advanced non-small cell lung cancer(NSCLC),and to compare the clinical effects and safety of the two treatments.Methods:112 cases of advanced NSCLC patients failed of first-line chemotherapy were randomized divided into gefitinib combined with chemotherapy group or chemotherapy group,receiving gefitinib,pemetrexed and cisplatin or pemetrexed and cisplatin as the second-line treatment,and the outcomes and safety were compared.Results:The objective response rate(ORR) and disease control rate(DCR) in the two groups were 36.5% and 18.3%(P=0.030),71.2% and 55.0%(P=0.035) respectively.The median progression free survival(PFS) was 8.7 months and 6.7 months(P=0.047),while the median overall survival(OS) was 10.6 months and 8.8 months(P=0.265).The level of CEA and CYFRA21-1 were significantly decreased in both groups,but the combination group was lower than chemotherapy group(P<0.05).As for adverse reactions,non-hematologic toxicities and hematologic toxicities were observed in the two groups.The skin rash and diarrhea were significantly higher in the combination group than in the chemotherapy group(P<0.05).Conclusion:The therapeutic effect of cisplatin-pemetrexed followed by gefitinib is better than the cisplatin-pemetrexed chemotherapy,and it can prolong the median PFS of the patients without increasing serious adverse reactions.

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Last Update: 2019-02-01