|Table of Contents|

Effect of timing of postoperative chemotherapy on the long-term prognosis of patients with colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
432-435
Research Field:
Publishing date:

Info

Title:
Effect of timing of postoperative chemotherapy on the long-term prognosis of patients with colon cancer
Author(s):
Zhan Zhixiang; Chen Liangfeng; Jia Xinli
Department of Oncology，Xinyang Central Hospital，Henan Xinyang 464000，China.
Keywords:
colon cancer; timing of chemotherapy; long-term prognosis; enzyme linked immunosorbent assay; toxic side effects; inflammatory factors
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2019.03.018
Abstract:
Objective：To investigate the effect of postoperative chemotherapy on the long-term prognosis of patients with colon cancer.Methods：From February 2011 to June 2013，105 patients with colon cancer received treatment in our department.All patients were treated by operation.According to the time of postoperative chemotherapy，35 patients were divided into 2 weeks group（n=35)，4 weeks group（n=35) and 6 weeks group（n=35).Chemotherapy started 2 weeks after operation in 2 weeks after operation group.Chemotherapy started 4 weeks after operation in 4 weeks after operation group.Chemotherapy started 6 weeks after operation in 6 weeks after operation group.All the chemotherapy regimens were selected for FOLFOX4 regimen.3 groups were treated with different time points of chemotherapy.Enzyme-linked immunosorbent assay（Elisa) was used to determine the level of tumor necrosis factor-α（TNF-α），interleukin-6（IL-6) and interleukin-10（IL-10).Followed up for 4~5 years to record the side effects and long-term survival of the three groups，and to compare the influence of different chemotherapeutic opportunities on the long-term prognosis of the patients.Results：The levels of TNF-α,IL-6 and IL-10 in 4 weeks after operation group were lower than those in 2 weeks after operation group and 6 weeks after operation group（P<0.05).There was no significant difference in the incidence of side effects between 2 weeks after operation group，4 weeks after operation group and the 6 weeks after operation group（P>0.05).The 1-year，3-year and 5-year survival rates after treatment in the 3 groups were analyzed.The postoperative 4 weeks after operation group was higher than that of the 2 weeks after operation group and the 6 weeks after operation group（P<0.05).Conclusion：Colon cancer patients have the best effect of chemotherapy at the fourth week after operation，which can help to reduce the level of inflammatory factors，improve the prognosis of patients and improve the survival rate.

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Memo

Memo:
河南省卫生和计划委员会基础研究项目（编号：JS20160100121）
Last Update: 2018-12-29