|Table of Contents|

Expression and clinical significance of Livin protein and STAT3 protein in bronchogenic carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
420-424
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of Livin protein and STAT3 protein in bronchogenic carcinoma
Author(s):
Chai Chunyan1Liu Yaping1Wang Tian1Du Jie2Li Yali3Xu Bangqiang1Zhao Yuan1
1.1st Impatient Area of West Court;2.The Health Examination Centre,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;3.Department of Respiratory Medicine,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
bronchogenic carcinomaLivin proteinSTAT3 proteinimmunohistochemistry
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.03.015
Abstract:
Objective:To investigate the expression of Livin protein and STAT3 protein in the tissues of lung cancer and their relationship with clinicopathological features.Methods:The protein expression of Livin and STAT3 gene in paraffin specimens of lung cancer and specimens of normal lung tissues were detected by SP immunohistochemistry.Results:The positive expression rate of Livin protein and STAT3 protein in lung cancer group were higher than that in the control group(P<0.05).The positive expression rates of Livin protein and STAT3 protein in lung tissue of male lung cancer patients,lymph node metastasis lung tissue,and lung cancer patients with smoking index≥400 were higher,and the differences were statistically significant(P<0.05).The expression of Livin protein in lung adenocarcinoma tissues was significantly higher than that in lung squamous cell carcinoma tissues.The differences were significant(P=0.009).The positive rate of STAT3 protein in poorly differentiated lung cancer was significantly higher than that in moderate differentiated lung cancer,and the difference was statistically significant(P=0.004).Livin protein and STAT3 protein in lung cancer had no obvious relationship with age and clinical stage(P>0.05).Livin protein expression was positively related to STAT3 protein expression in primary lung cancer.Conclusion:The overexpression of Livin protein and STAT3 protein in lung cancer tissue is expected to provide a new target for the diagnosis and gene therapy of tumor.The aberrant expression of Livin and STAT3 may play synergetic roles in process of carcinogenesis of lung cancer.

References:

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Last Update: 2018-12-29