[1]Amini A,Byers LA,Welsh JW,et al.Progress in the management of limited-stage small cell lung cancer[J].Cancer,2014,120(6):790-798.
[2]Owonikoko TK,Behera M,Chen Z,et al.A systematic analysis of efficacy of second-line chemotherapy in sensitive and refractory smallcell lung cancer[J].J Thorac Oncol,2012,7(5):866-872.
[3]Kalemkerian GP,Schneider BJ.Advances in small cell lung cancer[J].Hematol Oncol Clin N Am,2017,31(1):143-156.
[4]Fink TH,Huber RM,Heigener DF,et al.Topotecan/cisplatin compared with cisplatin/etoposide as first-line treatment for patients with extensive disease small-cell lung cancer:Final results of a randomized phase III trial[J].J Thorac Oncol,2012,7(9):1432-1439.
[5]Satouchi M,Kotani Y,Shibata T,et al.Phase III study comparing amrubicin plus cisplatin with irinotecan plus cisplatin in the treatment of extensive disease small-cell lung cancer:JCOG 0509[J].J Clin Oncol,2014,32(12):1262-1268.
[6]Von Pawel J,Jotte R,Spigel DR,et al.Randomized phase III trial of amrubicin topotecan as second-line treatment for patients with small cell lung cancer[J].J Clin Oncol,2014,32(35):4012-4019.
[7]Calvo E,Moreno V,Flynn M,et al.Antitumor activity of lurbinectedin (PM01183) and doxorubicin in relapsed small cell lung cancer:Results from a phase I study[J].Ann Oncol,2017,28(10):2559-2566.
[8]Chen HB,Dy G,Groman A,et al.P1.07-001 a phase II study of etirinotecan pegol (NKTR-102),a topoisomerase-I inhibitor polymer conjugate,in small cell lung cancer:Topic:Drug treatment alone and in combination with radiotherapy[J].J Thorac Oncol,2017,12(1):695-696.
[9]Tatematsu A,Shimizu J,Murakami Y,et al.Epidermal growth factor receptor mutations in small cell lung cancer[J].Clin Cancer Res,2008,14(19):6092-6096.
[10]Tanno S,Ohsaki Y,Nakanishi K,et al.Small cell lung cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib("Iressa",ZD1839)[J].Oncol Rep,2004,12(5):1053-1057.
[11]Moore AM,Einhorn LH,Estes D,et al.Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers:A hoosier oncology group phase II trial[J].Lung Cancer,2006,52(1):93-97.
[12]Sequist LV,Waltman BA,Dias-Santagata D,et al.Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors[J].Sci Transl Med,2011,3(75):75ra26.
[13]Spigel DR,Hainsworth JD,Simons L,et al.Irinotecan,carboplatin,and imatinib in untreated extensive-stage small-cell lung cancer:A phase II trial of the Minnie Pearl Cancer Research Network[J].J Thorac Oncol,2007,2(9):854-861.
[14]Schneider BJ,Kalemkerian GP,Ramnath N,et al.Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-Kit-positive,extensive-stage small-cell lung cancer[J].Clin Lung Cancer,2010,11(4):223-227.
[15]Miller AA,Pang H,Hodgson L,et al.A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (cancer and leukemia group B 30602)[J].J Thorac Oncol,2010,5(3):380-384.
[16]Ellis PM,Shepherd FA,Laurie SA,et al.NCIC CTG IND.190 phase I trial of dalotuzumab (MK-0646) in combination with cisplatin and etoposide in extensive-stage small-cell lung cancer[J].J Thorac Oncol,2014,9(3):410-413.
[17]Belani CP,Dahlberg SE,Rudin CM,et al.Three-arm randomized phase II study of cisplatin and etoposide (CE) vs CE with either vismodegib (V) or cixitumumab (Cx) for patients with extensive-stage small cell lung cancer(ES-SCLC)(ECOG 1508)[J].J Clin Oncol,2013,31(15):460.
[18]George J,Lim JS,Jang SJ,et al.Comprehensive genomic profiles of small cell lung cancer[J].Nature,2015,524(7563):47-53.
[19]Sartorius UA,Krammer PH.Upregulation of BCL-2 is involved in the mediation ofchemotherapy resistance in human small cell lung cancer cell lines[J].Int J Cancer,2002,97(5):584-592.
[20]Faber AC,Farago AF,Costa C,et al.Assessment of ABT-263 activity across a cancercell line collection leads to a potent combination therapy for smallcelllung cancer[J].Proceedings of the Naitonal Academy of Sciencesof the United States of America,2015,112(11):1288-1296.
[21]Nakajima W,Sharma K,Hicks MA,et al.Combination with vorinostat overcomes ABT-263(navitoclax) resistance of small cell lung cancer[J].Cancer Biol Ther,2016,17(1):27-35.
[22]Sabari JK,Lok BH,Laird JH,et al.Unravelling the biology of SCLC:Implications for therapy[J].Nat Rev Clin Oncol,2017,14(9):549-561.
[23]Rudin CM,Pietanza MC,Bauer TM,et al.Rovalpituzumabtesirine,a DLL3-targeted antibody-drug conjugate,in recurrentsmall cell lung cancer:A first in human,first in class,open-label,phase 1 study[J].Lancet Oncol,2017,18(1):42-51.
[24]Tiseo M,Boni L,Ambrosio F,et al.Italian,multicenter,phase III,randomized study of cisplatin plus etoposide with or without bevacizumab as first-line treatment in extensive-disease small-cell lung cancer:The GOIRC-AIFA FARM6PMFJM Trial[J].J Clin Oncol,2017,35(12):1281-1287.
[25]Li Q,Wu T,Jing L,et al.Angiogenesis inhibitors for the treatment of small cell lung cancer(SCLC):A meta-analysis of 7 randomized controlled trials[J].Medicine,2017,96(13):e6412.
[26]Lu HY,Jiang ZM.Advances in antiangiogenic treatment of small-cell lung cancer[J].Onco Targets Ther,2017,10:353-359.
[27]Ready NE,Pang HH,Gu L,et al.Chemotherapy with or without maintenance sunitinib for untreated extensive-stage small-cell lung cancer:A randomized,double-blind,placebo-controlled phase II study-CALGB 30504 (Alliance)[J].J Clin Oncol,2015,33(15):1660-1665.
[28]Sharma N,Pennell N,Nickolich M,et al.Phase II trial of sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer[J].Invest New Drugs,2014,32(2):362-368.
[29]Peng H,Zhang Q,Li J,et al.Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma[J].Oncotarget,2016,7(13):17220-17229.
[30]Zhao J,Zhang XL,Gong CJ,et al.Targeted therapy with apatinib in a patient with relapsed small cell lung cancer:A case report and literature review[J].Medicine,2017,96 (50):e9259.
[31]Hong W,Li H,Jin XY,et al.P1.07-053 apatinib for chemotherapy-refractory extensive stage SCLC:Results from a single-center retrospective study[J].J Thorac Oncol,2017,12(1):S729.
[32]Reck M,Bondarenko I,Luft A,et al.Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer:Results from a randomized,double-blind,multicenter phase 2 trial[J].Ann Oncol,2013,24(1):75-83.
[33]Reck M,Luft A,Szczesna A,et al.Phase III randomized trial of ipilimumab plus etoposide and platinum versus placebo plus etoposide and platinum in extensive-stage small-cell lung cancer[J].J Clin Oncol,2016,34(31):3740-3748.
[34]Wang A,Wang HY,Liu Y,et al.The prognostic value of PD-L1 expression for non- small cell lung cancer patients:A meta analysis[J].Eur J Surg Oncol,2015,41(4):450-456.
[35]Ishii H,Azuma K,Kawahara A,et al.Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer[J].J Thorac Oncol,2015,10(3):426-430.
[36]Ott PA,Hiret S,Kim D,et al.Pembrolizumab(MK3475) in patients with extensive-stage small cell lung cancer (SCLC):Preliminary safety and efficacy results from KEYNOTE-028[J].J Clin Oncol,2015,Suppl 33:a7502.
[37]Wang W,Lau R,Yu D,et al.PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25(Hi) regulatory T cells[J].Int Immunol,2009,21(9):1065-1077.
[38]Hellmann MD,Antonia SJ,Ponce S,et al.Nivolumab alone or with ipilimumab in recurrent small cell lung cancer:2-year survival and updated analyses from the CheckMate 032 trial[J].J Thorac Oncol,2017,12(1):393-394.