|Table of Contents|

Research progress of anti-tumor effect of EGCG and its related targets

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
331-335
Research Field:
Publishing date:

Info

Title:
Research progress of anti-tumor effect of EGCG and its related targets
Author(s):
Guo YanChen Xuesong
Department of Breast Medicine,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
EGCGtumorautophagyapoptosisangiogenesis
PACS:
R730.1
DOI:
10.3969/j.issn.1672-4992.2019.02.039
Abstract:
Epigallocatechin gallate (EGCG) is the main bioactive component of green tea and is a polyphenolic substance that belongs to the class of tea polyphenols.Over the years,it has been discovered that it has played a preventive and potential therapeutic role in anti-oxidation,anti-inflammatory,anti-cardiovascular diseases,anti-obesity,anti-diabetic,anti-neurological diseases,anti-tumor,and so on.It can interact with multiple protein targets and affect various biological pathways to exert its biological effects.For example,direct binding to autophagy-related protein LC3-I promotes the formation of LC3-II and promotes autophagy,acting on the PI3K/AKT pathway to affect cell autophagy,apoptosis,angiogenesis,and cell cycle regulation.Its anti-tumor role and its related targets are reviewed.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.81573001);国家自然科学基金面上项目(编号:81573001)
Last Update: 1900-01-01