|Table of Contents|

The clinical observation of decitabine combined with CAG regimen for the high-risk myelodysplastic syndrome and elderly acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
321-324
Research Field:
Publishing date:

Info

Title:
The clinical observation of decitabine combined with CAG regimen for the high-risk myelodysplastic syndrome and elderly acute myeloid leukemia
Author(s):
Ling Yiwen; Ye Haiyan; Zhao Ying; Chen Zhuowen
Department of Hematology,The First People's Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-Sen University),Guangdong Foshan 528000,China.
Keywords:
decitabine; CAG regimen; myelodysplastic syndrome; elderly acute myeloid leukemia
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2019.02.036
Abstract:
Objective To explore the efficacy and side effects of decitabine (DAC) combined with CAG regimen for high-risk myelodysplastic syndrome (MDS) and elderly acute myeloid leukemia (AML).Methods:A retrospective analysis was performed on the efficiency and side effects of DAC combined with CAG regimen (DAC 25 mg qd，d1~5,Ara-C 10 mg/m2 q12h，d6~12,Acla 12 mg/m2 qd，d6~9,G-CSF 200 μg/m2 qd，WBC＞20×109/L then stop) for 26 cases of high-risk MDS and elderly AML.Results:Among the 26 cases of high-risk MDS and elderly AML,complete remission (CR) rate was 42.3%.The clinical efficiency (CR+PR) was 65.4%.None of the patients died early.Median survival time was 16.2 months.Conclusion:The DAC combined with CAG regimen for high-risk MDS and elderly AML patients had definite therapeutic effect,and high safety.Due to the small sample cohort,multicenter randomized controlled trial is necessary.

References:

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