|Table of Contents|

The value of cerebrospinal fluid flow cytology diagnosis and differential diagnosis of children with acute lymphoblastic leukemia complicated with central nervous system disease

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
318-321
Research Field:
Publishing date:

Info

Title:
The value of cerebrospinal fluid flow cytology diagnosis and differential diagnosis of children with acute lymphoblastic leukemia complicated with central nervous system disease
Author(s):
Dong Deming; Xu Zhiliang
Department of Pediatrics，Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China.
Keywords:
cerebrospinal fluid flow cytology; children; acute lymphoblastic leukemia; central nervous system
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2019.02.035
Abstract:
Objective:To explore the value of cerebrospinal fluid flow cytologic diagnosis and identification of children with acute lymphoblastic leukemia complicated with central nervous system disease.Methods:The CSF samples from 89 children with ALL diagnosed in our hospital from January 2012 to June 2016,and cerebrospinal fluid flow cytometry (FCM) and cerebrospinal fluid cytology (CC) were used to detect the diagnosis of CNSL.The diagnosis of CNSL by two methods was compared.Results:23 cases of abnormal phenotypic cells were detected by cerebrospinal fluid FCM.The positive rate was 25.84%.10 cases of abnormal cells were detected by CSF cell morphology,the positive rate was 11.24%,and the positive rate of CSF FCM detection was significantly higher than that of CSF cell morphology (P＜0.05).For children with increased brain pressure,the positive rate of FCM detection is significantly higher than that of cell morphology detection (P＜0.05).For children with normal CSF,the positive rate of FCM detection is significantly higher than that of cell morphology detection (P＜0.05).Conclusion:The FCM of cerebrospinal fluid (CSF) is of important clinical significance in the diagnosis of CNSL in children with ALL,and is an important supplementary method for the morphological examination of cerebrospinal fluid cells.

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Memo

Memo:
湖北省自然科学基金资助项目(编号：2013CFB244)
Last Update: 1900-01-01