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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2019 02

Page:

311-315

Research Field:

Publishing date:

Info

Title:

Effects of dexmedetomidine and sevoflurane combined with fentanyl on serum NSE,S-100β,MDA,SOD and cerebral oxygen supply-demand balance in patients with supratentorial brain tumor

Author(s):

Chen Dongmei¹; Zhang Liang²; Han Zhiqiang¹; Zhong Haiyan¹; Fan Lingling¹; Du Yiri¹

1.Department of Anesthesiology of Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Hohhot 010050, China;2.Department of Anesthesiology,Erdos Central Hospital,Inner Mongolia Ordos 017000,China.

Keywords:

supratentorial brain tumor; dexmedetomidine; brain tissue; balance of cerebral oxygen supply and demand

PACS:

R739.41

DOI:

10.3969/j.issn.1672-4992.2019.02.033

Abstract:

Objective:To analyze the effects of dexmedetomidine and sevoflurane on the supply and demand balance and metabolism of cerebral oxygen in patients with supratentorial brain tumor.Methods:A prospective study was conducted in which patients with supratentorial brain tumors (90 cases) were divided into 2 groups.The control group received saline before induction of anesthesia and the observation group received dexmedetomidine.Record the cerebral oxygen supply-demand balance in patients before anesthesia induction (T1),tracheal intubation (T2),dura incision (T3),tumor removal (T4),surgery completion (T5),and postoperative 24 h (T6),namely brain oxygen uptake rate (CERO2),Blood oxygen saturation of the internal jugular vein (SjvO2),Poor venous oxygen content (Ca-jvO2),arterial blood oxygen content (CaO2).Comparison of patients at each time point of the brain energy metabolism index,the brain oxygenation index (LOI),glucose uptake rate (GluER),and brain lactate production rate (LacPR) levels.The levels of serum NSE,S-100β,MDA,and SOD in the jugular veins of the two groups at each time point were compared.Results:The levels of CERO2 and Ca-jvO2 in the observation group were lower than those in the control group at T3,T4,T5 and T6.The level of SjvO2 was higher in the observation group than in the control group,both being P＜0.05.LacPR was lower in the observation group than in the control group at T4 and T5 (P＜0.05).There was no significant difference in other indicators between the observation group and the control group (P＞0.05).The levels of S-100β,NSE,and MDA in the observation group were lower than those in the control group at T3,T4,T5,and T6.SOD levels were higher in the observation group than in the control group,both being P＜0.05.Conclusion:Dexmedetomidine can improve perioperative cerebral oxygen supply and demand balance in patients with supratentorial brain tumors,reduce free radical levels and multiple brain injury-specific protein levels,and effectively protect brain tissue.

References:

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Memo

Memo:

内蒙古自治区自然科学基金(编号：2017MS0832);内蒙古医科大学青年创新基金项目(编号:YKD2015QNCX017)

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