|Table of Contents|

Meta-analysis of Aidi injection combined with chemotherapy for advanced gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
281-286
Research Field:
Publishing date:

Info

Title:
Meta-analysis of Aidi injection combined with chemotherapy for advanced gastric cancer
Author(s):
Li Mengli1Wang Honghong2Huo Lichao3Liu Manxiang1Zhou Yongning4Guan Quanlin1
1.Department of Oncology;3.Department of Geriatrics;4.Department of Gastroenterology,The First Hospital of Lanzhou University,Gansu Lanzhou 730000,China;2.Department of Cardiovascular Medicine,Minion People's Hospital of Gansu Province,Gansu Lanzhou 730000,China.
Keywords:
Aidi injectionOxaliplatinadvanced gastric cancer
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.02.025
Abstract:
Objective:To evaluate the effectiveness and safety of S-1 and Oxaliplatin combined with Aidi injection for advanced gastric cancer.Methods:retrieval from PubMed,The Cochrane library,Web of Science,EMBASE,China Biology Medicine,China National Knowledge Infrastructure,VIP,Wanfang),randomized controlled trial about S-1 and Oxaliplatin combined with Aidi Injection for advanced gastric cancer were collected.Meta-analysis was conducted by Rev Man5.3 software after data extraction and quality evaluation.Results:There was statistical significance in effective rate of gastric cancer between 2 groups[OR=1.60,95%CI=(1.08,2.37),P=0.02].The incidence of leukopenia[OR=0.36,95%CI=(0.23,0.55),P<0.000 01],hemoglobin reduction[OR=0.45,95%CI=(0.21,0.96),P=0.04],thrombocytopenia[OR=0.49,95%CI=(0.29,0.81),P=0.006],nausea and vomiting[OR=0.45,95%CI=(0.31,0.68),P<0.000 1],diarrhea [OR=0.46,95%CI=(0.26,0.83),P=0.01],peripheral nerve toxicity[OR=0.32,95%CI=(0.18,0.56),P<0.000 1],abnormal liver function[OR=0.26,95%CI=(0.12,0.57),P=0.000 7] in trail group were lower than control group,with statistical significance.Conclusion:S-1 and Oxaliplatin combined with Aidi Injection for advanced gastric cancer can improve therapeutic efficacy and reduce the occurrence of adverse drug reaction.

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Memo

Memo:
国家重点研发计划(编号:2017YFC0908300)
Last Update: 1900-01-01