|Table of Contents|

Expression of IL-10 in H.pylori-associated gastritis and its correlation with COX-2 and iNOS

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
269-274
Research Field:
Publishing date:

Info

Title:
Expression of IL-10 in H.pylori-associated gastritis and its correlation with COX-2 and iNOS
Author(s):
Zhang Xiaoyan1; Ren Jiajia2; Zhao Hengfang1; Xu Junrong1; Li Xiaofang1
1.Department of Gastroenterology,Xi'an No.3 Hospital,Shaanxi Xi'an 710018,China;2.Ankang People's Hospital,Shaanxi Ankang 725000,China.
Keywords:
Helicobacter pylori; castritis; interleukin 10; cyclooxygenase-2; inducible nitric oxide synthase
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2019.02.022
Abstract:
Objective:To observe the expression of IL-10 in H.pylori-associated gastritis and its correlation with COX-2 and iNOS.Methods:74 cases of H.pylori related gastritis were selected.H.pylori was tested to determine H.pylori infection.The histopathological examination was tested to determine the pathological type,the degree of inflammation of the gastric mucosa.The immunohistochemistry was used to detect the expression of IL-10,COX-2 and iNOS in gastric mucosa.The H.pylori infection,pathological diagnosis and histological typing results were analyzed.The relationships between H.pylori infection and pathologic inflammation and pathological type in patients with chronic gastritis were analyzed.The relationship between IL-10 expression and H.pylori infection was analyzed.The expression of COX-2 and iNOS in H.pylori-positive gastritis in different pathological types were compared.The correlations between IL-10 and COX-2,iNOS expression in H.pylori positive gastritis patients were analyzed.Results:In 74 cases of chronic gastritis patients,59 cases were H.pylori positive and 15 cases were negative,the H.pylori detection rate was 79.73%.The patients of H.pylori positive and negative was significantly different in the degree of inflammation of the distribution(P＜0.05),manifested as H.pylori positive patients with moderate to severe inflammation,while the negative patients were mild mainly.The positive rate of H.pylori (93.55%) in IL-10 positive patients was significantly higher than that in patients with IL-10 negative (69.77%) (P＜0.05).There was no significant difference in pathological type (P＞0.05).The positive expression rate of COX-2 in H.pylori positive patients was 59.32%,which was significantly higher than that in H.pylori negative patients (20.00%) (P＜0.01),and the positive expression rate of iNOS was 61.02%,which was significantly higher than that of negative patients(20.00%) (P＜0.01).There was no significant difference in the positive rate of IL-10 between different pathologic gastritis H.pylori positive patients (P＞0.05).The positive rate of COX-2 (84.62%) in patients with H.pylori positive gastritis (IM+Dy) was higher than that in CSG (44.00%) patients (P＜0.05),and the positive rate of iNOS (80.95%) in CAG patients was significantly higher than that in patients with CSG (44.00%) (P＜0.05).The expression of IL-10 in patients with H.pylori positive gastritis was significantly negatively correlated with COX-2 (r=-0.566,P＜0.001) and iNOS (r=-0.465,P＜0.001).Conclusion:IL-10 is a protective factor for H.pylori-associated gastritis and has a high positive rate in H.pylori-positive patients.The expression of COX-2 and iNOS was negatively correlated with IL-10 in H.pylori positive patients,and could reduce the risk of malignant lesions in patients with chronic gastritis by down-regulating the expression of COX-2 and iNOS. 【Key words】 Modern Oncology 2019,27(02)：0269-0274

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