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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2019 02

Page:

265-269

Research Field:

Publishing date:

Info

Title:

Correlation of preoperative platelet/lymphocyte ratio with clinical pathological characteristics and survival time in pancreatic cancer patients with radical resection

Author(s):

Ni Meng¹; Yin Tao²; Fan Hongwei¹; Liu Chi³

1.Department of Gastroenterology,Nanyang Central Hospital/Nanyang Hospital,Zhengzhou University,Henan Nanyang 473000,China;2.Department of Pancreatic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China;3.Department of General Surgery,Nanyang Central Hospital/Nanyang Hospital,Zhengzhou University,Henan Nanyang 473000,China.

Keywords:

pancreatic cancer; platelet; lymphocyte; clinical pathological features; survival time; correlation

PACS:

R735.9

DOI:

10.3969/j.issn.1672-4992.2019.02.021

Abstract:

Objective:To investigate the correlation of preoperative platelet/lymphocyte ratio (PLR) with clinical pathological characteristics and survival time in pancreatic cancer patients with radical resection.Methods:The clinicopathological data of 86 patients who underwent radical resection of pancreatic cancer in our hospital from May 2010 to May 2014 were retrospectively analyzed.According to preoperative PLR of ROC,patients were divided into with high PLR and with low PLR.The clinicopathological features and 1-year survival rate were compared between the two groups.Univariate analysis and Cox proportional hazards regression model were used to analyze the prognostic survival factors of pancreatic cancer patients.Results:The ROC curve showed that the best critical value of PLR to predict the survival time of the patients with radical pancreatic cancer was 250.2,according to the critical value,the high PLR group (PLR>250.2,40 cases) and the low PLR group (PLR<250.2,46 cases).The age,tumor T stage,and tumor N stage in the high PLR group were significantly higher than those in the low PLR group (P＜0.05).The median survival time and 1-year survival rate in the high-PLR group were significantly lower than those in the low-PLR group (P＜0.05).Univariate analysis showed that age,tumor T staging and tumor N staging,preoperative PLR were correlated with prognosis survival after pancreatic cancer (P＜0.05).Multivariate Cox stepwise regression analysis revealed that advanced T stage lesions (T3-4),advanced N stage metastasis (N1),and PLR≥250.2 preoperatively were all independent risk factors for prognosis survival after pancreatic cancer (P＜0.05).Conclusion:Preoperative PLR is closely related to age,tumor T stage,and tumor N stage in patients with pancreatic cancer,and preoperative high PLR level is an independent risk factor influencing prognosis survival of pancreatic cancer patients.Therefore,it can be used as one of the effective indicators of prognosis.

References:

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Memo

Memo:

National Natural Science Foundation of China(No.81372665);国家自然科学基金资助项目（编号：81372665）；教育部博士点新青年教师基金项目（编号：200804871112）

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