|Table of Contents|

The distribution of pathogenic bacteria in lung infection after chemotherapy in elderly patients with lung cancer and its effect on immune function

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
233-236
Research Field:
Publishing date:

Info

Title:
The distribution of pathogenic bacteria in lung infection after chemotherapy in elderly patients with lung cancer and its effect on immune function
Author(s):
Liu Yu1; Wang Yao2
1.Outpatient Department of Internal Medicine;2.Elderly Demonstration Department,Beijing Geriatric Hospital,Beijing 100095,China.
Keywords:
lung cancer; chemotherapy; pulmonary infection; pathogenic bacteria; immune function
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.02.013
Abstract:
Objective:To investigate the distribution of pathogenic bacteria in lung infection after chemotherapy in elderly patients with lung cancer and its effect on immune function.Methods:183 patients with lung cancer chemotherapy were selected from January 2015 to January 2018 in our hospital.The analysis of pulmonary infection,pathogenic bacteria and drug resistance of lung infection,and the changes of immune function indexes in patients with lung infection and uninfected.Results:82 cases of lung infection occurred in lung cancer patients after chemotherapy,and the incidence of lung infection was 44.81%.93 strains of pathogenic bacteria were isolated and cultured in 82 cases of pulmonary infection,including 59 Gram-negative bacteria,30 Gram-positive bacteria and 4 fungi.Gram-negative bacteria were mainly 27 strains of Pseudomonas aeruginosa and 13 strains of Klebsiella pneumoniae.Gram-positive bacteria were mainly Staphylococcus aureus 11 strains and coagulase negative Staphylococci 10 strains.Among the main Gram-negative bacteria,Pseudomonas aeruginosa had higher resistance rates to cefoperazone and ceftazidime,92.59% and 85.18% respectively,and the resistance rates of Klebsiella pneumoniae to cefepime and ceftazidime were 84.61% and 76.92%,respectively.Among the main Gram-positive bacteria,Staphylococcus aureus had higher resistance rates to penicillin G and erythromycin,90.91% and 81.82% respectively,and coagulase negative Staphylococci had higher resistance rates to erythromycin and penicillin G,100% and 80% respectively.The CD3+,CD4+ and CD4+/CD8+ in the lung infection group were lower than those in the uninfected group (P＜0.05).Conclusion:The distribution of pathogenic bacteria of pulmonary infection in elderly patients with lung cancer after chemotherapy were mainly Gram-negative bacteria,Gram-negative bacteria were higher rate of cephalosporins,higher rate of Gram-positive bacteria were resistant to penicillin and erythromycin,and decreased immune function in patients with pulmonary infection.

References:

［1］Watanabe K,Shinkai M,Tei Y,et al.Chemotherapy in non-small cell lung cancer patients receiving oxygen therapy［J］.Oncol Res Treat,2016,39(10):587-590.
［2］Avci N,Hartavi M,Kaan T,et al.Retrospective analysis of the microbiological spectrum of pneumonia in Turkish patients with lung cancer［J］.Contemporary Oncology,2016,20(1):63-66.
［3］Wang L,Li Y,Zhang X,et al.Characteristics of nosocomial infection and its effects on the survival of chemotherapy patients with advanced non-small cell lung cancer［J］.Oncology Letters,2017,14(6):7379-7383.
［4］Jin SY,Huang WH,Wang R,et al.Analysis of the distribution and drug resistance of the pathogenic bacteria of lung infection after palliative treatment of lung cancer ［J］.Chinese Journal of Infection Science,2016,26(15):3392-3394.［靳生艳,黄文辉,王蓉,等.肺癌患者姑息治疗后肺部感染病原菌分布与耐药性分析［J］.中华医院感染学杂志,2016,26(15):3392-3394.］
［5］Guo CX,Shi HM,Li F,et al.Pathogenic bacteria and drug sensitivity analysis of lung infection in patients with advanced lung cancer ［J］.Chinese Journal of Nosocomial Infection,2016,26(16):3702-3704.［郭彩霞,石红梅,李飞,等.晚期肺癌患者肺部感染病原菌与药敏分析［J］.中华医院感染学杂志,2016,26(16):3702-3704.］
［6］Ministry of Health of People's Republic of China.Diagnostic criteria for nosocomial infection (trial implementation) ［J］.Chinese Journal of Medicine,2001,81(5):314-320.［中华人民共和国卫生部.医院感染诊断标准(试行)［J］.中华医学杂志,2001,81(5):314-320.］
［7］Yu P,Wang L,Shi L,et al.Clinical study of Klebsiella pneumoniae infection in postoperative lung cancer patients ［J］.Chinese Journal of Nosocomial Infection,2016,26(12):2654-2656.［于鹏,王亮,史蕾,等.肺癌患者术后肺炎克雷伯菌感染的临床研究［J］.中华医院感染学杂志,2016,26(12):2654-2656.］
［8］Wu LG,Liu QM.The distribution of pathogenic bacteria and drug resistance of lung infection in the elderly lung cancer patients at the basic level hospital ［J］.China Journal of Health Inspection,2016,5(23):3477-3480.［吴连根,刘旗明.基层医院老年肺癌患者肺部感染的病原菌分布及耐药性分析［J］.中国卫生检验杂志,2016,5(23):3477-3480.］
［9］Wang P,Zhang D,Guo XG,et al.Analysis of the distribution and drug resistance of lung infection in elderly patients with non-small cell lung cancer:progress in modern biomedicine ［J］.Progress in Modern Biomedicine,2017,14(32):6260-6266.［王鹏,张东,郭学光,等.老年非小细胞肺癌患者肺部感染病原学分布与耐药性分析［J］.现代生物医学进展,2017,14(32):6260-6266.］
［10］Shen YN,Miao QZ.Characteristics of lung infection and antibiotic resistance in advanced lung cancer patients before and after chemotherapy ［J］.Zhejiang Trauma Surgery,2016,21(4):671-672.［沈幼南,缪千状.晚期肺癌患者化疗前后的肺部感染及抗菌药物耐药特征［J］.浙江创伤外科,2016,21(4):671-672.］
［11］Wei JJ.Pathogen culture and drug sensitivity analysis of lung cancer in elderly lung cancer patients before and after radiotherapy and chemotherapy ［J］.Practical Journal of Cancer,2017,32 (3):466-468.［魏娟娟.老年肺癌放化疗前后肺部感染的病原菌培养及药敏分析［J］.实用癌症杂志,2017,32(3):466-468.］
［12］Yang GQ,Liu WC,Liu ZR.Analysis of pathogens and drug resistance of lung cancer patients with lung infection after chemotherapy ［J］.Chinese Journal of Hygiene Test,2017,14(9):1341-1343.［杨桂强,刘文超,刘滋润.肺癌患者化疗后肺部感染病原菌及耐药分析［J］.中国卫生检验杂志,2017,14(9):1341-1343.］
［13］Zhu K,Chen HR,Hu R,et al.Effects of Chuan Ke injection combined with chemotherapy on immune function in elderly patients with non-small cell lung cancer and clinical efficacy ［J］.Tumor Pharmacy,2017,7(1):44-49.［朱可,陈汉锐,胡蓉,等.喘可治注射液联合化疗对老年非小细胞肺癌患者免疫功能的影响及临床疗效［J］.肿瘤药学,2017,7(1):44-49.］
［14］Lu S,Sun Y,Chen Z,et al.The clinical efficacy of different chemotherapy regimens combined with operation on non small cell lung cancer and its effect on the immune function of patients with ［J］.Modern Biomedical Progress,2016,16(30):5882-5885.［陆莎,孙盈,陈召,等.不同化疗方案联合手术治疗非小细胞肺癌的临床疗效及对患者免疫功能的影响分析［J］.现代生物医学进展,2016,16(30):5882-5885.］
［15］Liu LB,Huang G,Guo SJ,et al.The distribution of pathogenic bacteria and the influence on the immune function of lung infection after chemotherapy in patients with advanced lung cancer ［J］.Chinese Journal of Nosocomial Infection,2017,27(22):5105-5108.［刘联斌,黄刚,郭守俊,等.晚期肺癌患者化疗后肺部感染的病原菌分布和对免疫功能的影响研究［J］.中华医院感染学杂志,2017,27(22):5105-5108.］

Memo

Memo:
北京市卫计委年度专项课题（编号：2017BW371）
Last Update: 1900-01-01