|Table of Contents|

The value of tumor markers in cerebrospinal fluid in the diagnosis of leptomeningeal metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 02
Page:
216-219
Research Field:
Publishing date:

Info

Title:
The value of tumor markers in cerebrospinal fluid in the diagnosis of leptomeningeal metastasis
Author(s):
Li Yongsheng; Zhao Jin; Li Jijun; Zhang Jinghua; Gao Jinghua; Qin Ce; Wang Yang; Shi Ying; Tian Wen; Wu Yuanyuan; Liu Zhibao
Department of Oncology,Cangzhou Central Hospital,Hebei Cangzhou 061000,China.
Keywords:
leptomeningeal metastasis; tumor markers of cerebrospinal fluid; cytological examination; strengthen MRI
PACS:
R739.45
DOI:
10.3969/j.issn.1672-4992.2019.02.009
Abstract:
Objective:By analyzing the clinical features,enhanced MRI and tumor markers in cerebrospinal fluid,we tried to improve the understanding of leptomeningeal metastasis and find effective examination methods.Methods：A retrospective analysis was performed on 23 patients diagnosed with meningeal carcinomatosis from 2011.10 to 2017.6 in our hospital of medical oncology.The results of clinical manifestations,meningeal enhanced MRI,detection of tumor markers in cerebrospinal fluid,and tumor markers in serum were statistically analyzed.Results：The positive expression rate of tumor marker in cerebrospinal fluid,cytological examination and image examination was 82.61%,56.52% and 65.22% respectively.CEA,a single tumor marker,as an independent observer,when it was high in cerebrospinal fluid,the positive rate of cytology and meningeal enhanced MRI in cerebrospinal fluid were also increased.When several tumor markers were expressed,the positive detection rate of cytological examination and abnormal changes in enhanced MRI occurrencly enhanced.The three roles were closely related and had statistically significant.The positive expression of tumor markers in the cerebrospinal fluid is corresponding to the serum.Conclusion:Cytological examination of cerebrospinal fluid and enhanced MRI are the main diagnostic basis for meningeal metastases.The combination of tumor markers in cerebrospinal fluid and MRI examination can obviously improved the accuracy of diagnosis,and made up the defects of cytological examination.

References:

［1］Kesari S,Batchelor TT.Leptomeningeal metastases［J］.Neurol Clin,2003,21(1):25-66.
［2］Posner JB,Chernik NL.Intracranial metastases from systemic cancer［J］.Adv Neurol,1978,19:579-592.
［3］Wang Y,Gao Y,Xu DZ,et al.The diagnosis and treatments progress of meningeal carcinomatosis［J］.Chinese Journal of Clinical Neurosurgery,2013,18(12):760-762.［王勇,高烨,许德志,等.脑膜癌病的诊治进展［J］.中国临床神经外科杂志,2013,18(12):760-762.］
［4］Shi Q,Pu CQ,Wu WP,et al.Study on normal reference value of tumor markers in cerebrospinal fluid［C］.Paper Compilation of the Eleventh National Symposium on Neurology,2008.［石强,蒲传强,吴卫平,等.脑脊液肿瘤标志物正常参考值研究［C］.第十一届全国神经病学学术会议论文汇编,2008.］
［5］Le Rhun E,Massin F,Tu Q,et al.Development of a new method for identification and quantification in cerebrospinal fluid of malignant cells from breast carcinoma leptomeningeal metastasis［J］.BMC Clin Pathol,2012,12:21.
［6］Herrlinger U,Forschler H,Kuker W,et al.Leptomeningeal metastasis:survival and prognostic factors in 155 patients［J］.J Neurol Sci,2004,223(2):167-178.
［7］Bigner SH.Cerebrospinal fluid (CSF) cytology:current status and diagnostic applications［J］.J Neuropathol Exp Neurol,1992,51(3):235-245.
［8］Passarin MG,Sava T,Furlanetto J,et al.Leptomeningeal metastasis from solid tumors:a diagnostic and therapeutic challenge［J］.Neu-rol Sci,2015,36(1):117-123.
［9］Pan Z,Yang G,Wang Y,et al.Thinprep plus Papanicolaou stain method is more sensitive than cytospin-coupled Wright Giems stain methodin cerebrospinal fluid cytology for diagnosis of leptomeningeal metastasis from solid tumors［J］.PLoS One,2015,10(4):e0122016.
［10］Tu Q,Wu X,Le Rhun E,et al.Cell Search technology applied to thedetection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis［J］.Lung Cancer,2015,90(2):352-357.
［11］Wang Y,Springer S,Zhang M,et al.Detection of tumor-derive dDNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord［J］.Proc Natl Acad Sci USA，2015,112(31):9704-9709.
［12］Elena I Pentsova,Ronak H Shah,Jiabin Tang，et al.Evaluating cancer of the central nervous system through next-generation sequencing of cerebrospinal fluid［J］.J Clin Oncol,2016,34(20):2404-2415.
［13］Wang P,Piao Y,Zhang X,et al.The concentration of CYFRA21-1,NSE and CEA in cerebro-spinal fluid can be useful indicators for diagnosis of meningeal carcinomatosis of lung cancer［J］.Cancer Biomark,2013,13(2):123-130.
［14］Porto L,Kieslich M,Bartels M,et al.Leptomeningeal metastases in pediatrics:magnetic resonance image manifestations and correlation with cerebral spinal fluid cytology［J］.Pediatr Int,2010,52(4):541-546.
［15］Brower JV,Saha S,Rosenberg SA,et al.Management of leptomeningeal metastases:Prognostic factors and associated outcomes［J］.J Clin Neurosci,2016,27:130-137.
［16］Straathof CS,de Bruin HG,Dippel DW,et al.The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis［J］.J Neurol,1999,246(9):810-814.
［17］Freilich RJ,Krol G,DeAngelis LM.Neuroimaging and cerebrospinalfluid cytology in the diagnosis of leptomeningeal metastasis［J］.Ann Neurol,1995,38(1):51-57.
［18］Pavlidis N． The diagnostic and therapeutic management of lepto-meningeal carcinomatosis［J］．Ann Oncol，2004，15(Suppl 4):285－291．
［19］Shi Q,Pu C,Huang X,et al.Optimal cut-off values for tumor markers in cerebrospinal fluid with ROC curve analysis［J］.Frontiers in Bioscience (Elite Edition),2010,3:1259-1264.
［20］Wang P,She CH,Li P,et al.Significance of tumor markers in the diagnosis of lung cancer meningeal metastasis［J］.Chin J Clin Oncol,2008,35(2):61-64.［王鹏,佘春华,李鹏,等.肿瘤标志物在肺癌脑膜转移辅助诊断中的应用［J］.中国肿瘤临床,2008,35(2):61-64.］

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