|Table of Contents|

Diagnostic value of serum HE4,NSE and CYFRA21-1 in lung cancer and lymph node metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
67-70
Research Field:
Publishing date:

Info

Title:
Diagnostic value of serum HE4,NSE and CYFRA21-1 in lung cancer and lymph node metastasis
Author(s):
Wang YingLi PeizhangLiu JinfengPang NaiqiLi JiawenLiu Miaofeng
Guangxi Institute for Cancer Research,Guangxi Nanning 530021,China.
Keywords:
lung cancerlymph node metastasisHE4NSECYFRA21-1
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2019.01.017
Abstract:
Objective:To study the significance of serum humanepididymis 4(HE4),neuron specific enolase(NSE) and cytokerantin-19-fragment(CYFRA21-1) levels in lung cancer patients with lung cancer diagnosis and lymph nodes metastasis by Logistic regression and receiver operating characteristic(ROC) curve analysis.Methods:Electrochemiluminescence method was used to detect serum HE4,NSE and CYFRA21-1 levels in both 88 diagnosed lung cancer patients and 50 healthy controls.Serum HE4,NSE and CYFRA21-1 levels among lung cancer patients with different lymph node metastasis were compared.Logistic regression and ROC cure analysis were conducted to explore the clinical significance of serum HE4,NSE and CYFRA21-1 levels for lymph node metastasis in lung cancer patients.Results:The serum HE4,NSE and CYFRA21-1 levels in lung cancer patients with lymph node metastasis were significantly higher than those without lymph node metastasis(P<0.05).Logistic regression analysis showed that tumor size,pathological type,depth of invasion,TNM stage,NSE and CYFRA21-1 levels were independent risk factors for lymph node metastasis occurs in lung cancer.The results from ROC cure analysis showed that the area under the curve(AUC) value of HE4,NSE and CYFRA21-1 were 0.832 (P=0.000,95%CI:0.777~0.921),0.726(P=0.000,95%CI:0.686~0.817) and 0.810(P=0.000,95%CI:0.737~0.907) respectively.HE4 at threshold of 168.5 pg/L,NSE at threshold of 52.6 μg/L and CYFRA21-1 at threshold of 26.4 μg/L have the best predictive value on lymph node metastasis occurs in lung cancer. Conclusion:Serum HE4,NSE and CYFRA21-1 levels have important value in diagnosing lung cancer and monitoring lymph node metastasis,it can provide more valuable help for clinical treatment of lung cancer by Logistic regression and ROC curve analysis.

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Last Update: 2018-11-30