|Table of Contents|

The research of CXCL14 as a diagnostic marker for hepatocellular carcinoma with diabetes

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 22
Page:
3656-3660
Research Field:
Publishing date:

Info

Title:
The research of CXCL14 as a diagnostic marker for hepatocellular carcinoma with diabetes
Author(s):
Zhang Ting; Wu Dongming; Xu Ying
The First Affiliated Hospital of Chengdu Medical College,Sichuan Chengdu 610500,China.
Keywords:
hepatocellular carcinoma; diabetes mellitus; CXCL14
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2017.22.028
Abstract:
Objective:To screen the molecular markers of hepatocellular carcinoma (HCC) with diabetes mellitus (DM)，to detect its expression in liver cancer and diabetes，and to provide the molecular markers for early diagnosis of HCC with DM.Methods：The differentially expressed molecule in HCC and diabetic patients was screened by a comprehensive analysis of GEO and TCGA databases,and the expression of the molecular in normal tissue and HCC tissue was tested on tissue microarray.ELISA was used to detect the expression of the molecular in serum samples from diabetic patients.Clinical blood samples were collected to detect the expression of the molecular marker in normal people,HCC with DM or without DM.Then,the correlation between the molecular marker and blood glucose was analyzed in 15 patients with liver cancer.Results：By analyzing GEO and TCGA database,we got CXCL14 which was differentially expressed in HCC with DM.The results of tissue microarray and ELISA showed that the expression of CXCL14 was lower in HCC patients and diabetic patients,compared with normal people.The expression of CXCL14 in HCC with DM patients was significantly lower than that in HCC without DM.The expression level of CXCL14 was negatively correlated with the concentration of blood glucose in HCC patients.Conclusion:CXCL14 may be associated with the occurrence and development of hepatocellular carcinoma with diabetes mellitus,early detection of CXCL14 in serum of patients with hepatocellular carcinoma may be a predictor of diabetes mellitus.

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四川省教育厅项目(编号：15ZA0264,15ZB0245);四川省教育厅高校科研创新团队(编号：17TD0012);四川省卫生和计划生育委员会项目(编号：16ZD040)
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