|Table of Contents|

miR-873 supresses invasion and metastasis of hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 22
Page:
3648-3652
Research Field:
Publishing date:

Info

Title:
miR-873 supresses invasion and metastasis of hepatocellular carcinoma
Author(s):
Chang Weiping; Yu Zhaoxiang
Department of General Surgery,The First Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710077,China.
Keywords:
miR-873; hepatocellular carcinoma; invasion; metastasis
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2017.22.026
Abstract:
Objective:To detect the expression level of miR-873 in hepatocellular carcinoma,and explore the clinical significance and functions of miR-873 in invasion and metastasis of hepatocellular carcinoma.Methods:Real-time PCR was performed to investigate the miR-873 expression in 90 paired HCC tissues and adjacent normal tissues.The clinical significance of miR-873 and its effects on HCC patients prognosis were analysed by statistics analysis.Real-time PCR was performed to detect the miR-873 expression in HCC cell lines.Transwell assay was applied to explore the functions of miR-873 in metastasis and invasion of HCC.Results:The expression level of miR-873 in both HCC tissues and cell lines was significantly down-regulared(P＜0.05),and miR-873 expression level was associated with tumor number,vein invasion,Edmondson-Steiner grading and tumor-node-metastasis (TNM) stage.Kaplan-Meier survival curves revealed that patients with lower miR-873 expression had a significantly reduced survival rate than those with high miR-873 expression (P＜0.05),and miR-873 could be an independent prognostic factor for HCC patients.Results of Transwell assay suggested that miR-873 could supress invasion and metastasis of HCC cells.Conclusion:miR-873 was down-regulated in HCC,and was associated with tumor number,vein invasion,Edmondson-Steiner grading and TNM stage and prognosis of HCC patients.miR-873 could supress invasion and metastasis of HCC cells.

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