|Table of Contents|

The expression of HIF-1α and HIF-2α and its clinical significance in stomach cancer tissue

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 22
Page:
3635-3639
Research Field:
Publishing date:

Info

Title:
The expression of HIF-1α and HIF-2α and its clinical significance in stomach cancer tissue
Author(s):
Ma Li; Yu Shuxia; Qin Xu
Daxing Hospital Affiliated Capital Medical University,Beijing 102600,China.
Keywords:
stomach cancer; HIF-1α; HIF-2α; gene expression
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2017.22.023
Abstract:
Objective:To determine the expression of HIF-1α and HIF-2α in stomach cancer and its clinical significance.Methods:Collecting postoperative carcinoma tissues and adjacent tissues of 62 cases patients with stomach cancer.Immunohistochemical staining and Western blot method were used as detect the expression level of HIF-1α and HIF-2α.Results:The expression of HIF-1α and HIF-2α were both significantly higher than that in the para-carcinoma tissue,and the difference was statistically significant (P＜0.05).Correlation analysis found that the high expression of HIF-1α in cancer tissue was significantly associated with T stage，tumor diameter and different location of gastric tissue.And all of them were independent factors related to the abnormal expression of HIF-1 according to the results of multivariate Logistic regression analysis.The high expression of HIF-2α in cancer tissue was significantly associated with the T stage，tumor diameter and lymph node metastasis.Conclusion:HIF-1α and HIF-2α is abnormal expression in stomach cancer,and there was no significant correlation,suggesting that there may be different physiological functions and regulation mechanism between them.

References:

［1］Ahmedin J,Freddie B,Center MM,et al.Global cancer statistics［J］.Ca A Cancer Journal for Clinicians,2011,61(2):69-90.
［2］Tunceroglu A,Jabbour SK.Gastric cancer:past accomplishments,present approaches and future aspirations［J］.Clinical Practice,2017,10(1):47-77.
［3］Wang K,Yuen ST,Xu J,et al.Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer［J］.Nature Genetics,2014,46(6):573-582.
［4］Kietzmann T,Mennerich D,Dimova EY.Hypoxia-inducible factors (HIFs) and phosphorylation:Impact on stability,localization,and transactivity［J］.Frontiers in Cell & Developmental Biology,2016,4:105.
［5］Zhang K,Han ES,Dellinger TH,et al.Cinnamon extract reduces VEGF expression via suppressing HIF-1α gene expression and inhibits tumor growth in mice［J］.Molecular Carcinogenesis,2017,56(2):436.
［6］Katherine L Talks,Helen Turley,Kevin C Gatter,et al.The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues,cancers,and tumor-associated macrophages［J］.American Journal of Pathology,2000,157(2):411-421.
［7］Tanam M,AloktaIshika,Bhossain M,et al.A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms:association with cancers［J］.Journal of Geophysical Research Oceans,2015,3(29):226-236.
［8］Shi S,Xu J,Zhang B,et al.VEGF promotes glycolysis in pancreatic cancer via HIF1α up-regulation［J］.Current Molecular Medicine,2016,16(999):1.
［9］El-Naggar A,Veinotte C,Cheng H,et al.Translational activation of HIF1α by YB-1 promotes sarcoma metastasis［J］.Cancer Cell,2015,27(5):682-697.
［10］David V,Guillaume D,Arnaud A,et al.Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth［J］.Oncotarget,2014,5(4):1004-1013.
［11］Wei-Wei T,Guang-Hui T,Xie-Xiao C,et al.HIF2α is associated with poor prognosis and affects the expression levels of survivin and cyclin D1 in gastric carcinoma［J］.International Journal of Oncology,2015,46(1):233-242.
［12］Wang Y,Li Z,Zhang H,et al.HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer［J］.Cancer Biology & Therapy,2010,10(4):376-382.
［13］Corzo CA,Thomas C,Lily L,et al.HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment［J］.Cancer Letters,2015,207(11):2439-2453.
［14］Wilkinson NW,Howe J,Gay G,et al.Differences in the pattern of presentation and treatment of proximal and distal gastric cancer:results of the 2001 gastric patient care evaluation［J］.Annals of Surgical Oncology,2008,15(6):1644-1650.
［15］Wang QW,Wang QZ,Yu DH,et al.Investigation of H.pylori and CagA genes in gastric cancer with different parts,differention and origin［J］.Chinese J Microeology,2010(2):130-134.［汪强武,王启之,于东红,等.不同部位、分化和起源胃癌中H.pylori、CagA基因的探讨［J］.中国微生态学杂志,2010,2:130-134.］
［16］Miao LF,Lei RX,Guo M.Expression of HER-2 protein in advanced gastric cancer of different sites［J］.Chinese Journal of Gastroenterology,2014,19(10):618-620.［苗兰芳,雷瑞雪,郭梅.进展期不同部位胃癌HER-2蛋白的表达［J］.胃肠病学,2014,19(10):618-620.］
［17］Shi X,Meng L,Ding Z,et al.Significance of EGFR,Her-2,and HIF-1α expression in esophageal squamous cell carcinoma［J］.Chinese Journal of Clinicians,2014,24:256-260.
［18］Ding Zhaojun,Meng Lingxin,Zhou Xiaoming,et al.The application of EGFR,Her-2,HIF-1 alpha,p53 for neoadjuvant chemotherapy curative effect prediction in advanced esophageal squamous carcinoma［J］.Modern Oncology,2016,24(20):3209-3212.
［19］Kunisaki C,Shimada H,Nomura M,et al.Distribution of lymph node metastasis in gastric carcinoma［J］.Hepatogastroenterology,2006,53(69):468-472.
［20］Kato M,Asaka M,Shimizu Y,et al.Relationship between Helicobacter pylori infection and the prevalence,site and histological type of gastric cancer［J］.Alimentary Pharmacology & Therapeutics,2004,20(Supplement s1):85-89.
［21］Gurjeet K,Subathra S,Bhupinder S.Differences in the pattern of gastric carcinoma between north-eastern and north-western peninsular Malaysia:a reflection of Helicobacter pylori prevalence［J］.Med J Malaysia,2004,59(4):560-561.

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