|Table of Contents|

The expression and significance of MMP-9 in triple negative breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 22
Page:
3623-3626
Research Field:
Publishing date:

Info

Title:
The expression and significance of MMP-9 in triple negative breast cancer
Author(s):
Ma Li1; Wu Jie1; Jin Yaofeng1; Ma Xiaobin2
1.Department of Pathology;2.Department of Oncology,The Second Affiliated Hospital,Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
triple negative breast cancer; MMP-9; recurrence and metastasis
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.22.019
Abstract:
Objective:To investigate the expression and significance of MMP-9 in triple negative breast cancer (TNBC).Methods:158 cases of breast invasive ductal carcinoma in our hospital were retrospectively analyzed.According to the expression of ER，PR，HER-2,we categorized those paitent into triple negative breast cancer group (65 cases) and non triple negative breast cancer (93 cases).The different expression of MMP-9 was detected by immunohistochemieal technology in two groups.We analyzed the relationship between the expression of MMP-9 and clinical and pathological features in TNBC,and investigated the effect of MMP-9 on the rate of recurrence and metastasis in 3 years.Results:The expression of MMP-9 in TNBC was significantly higher than that of no-TNBC (P＜0.05).The expression of MMP-9 in TNBC was associated with TNM stage,histological grade,lymph node status and vascular invasion(P＜0.05),but not with age and size of the tumor (P＞0.05).The rate of recurrence and metastasis in positive expression of MMP-9 in TNBC was 76.09%,which was significantly higher than negative expression of MMP-9 in TNBC (47.37%),and the statistically significant was found (P＜0.05).Conclusion:The expression of MMP-9 in TNBC was significantly higher than that of no-TNBC,and its expression is associated with the rate of recurrence and metastasis in 3 years.

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Memo

Memo:
陕西省国际合作重点项目(编号：2016KW-008)；陕西省自然科学基础研究计划(编号：2015JM8430)
Last Update: 1900-01-01