|Table of Contents|

Expression and clinical significance of FBXL5 in colon cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 18
Page:
2934-2938
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of FBXL5 in colon cancer
Author(s):
Wang Tianming1; Li Xiaoli2; Tian Yin1; Zhao Haifeng1
1.Department of Oncology,the First Affiliated Hospital of Jiamusi University,Heilongjiang Jiamusi 154003,China;2.Department of Medical Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150080,China.
Keywords:
colon cancer; E3 ubiquitin ligases; F-box and leucine-rich repeat proteins(FBXL5); epithelial-mesenchymal transition
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2017.18.020
Abstract:
Objective:To investigate FBXL5 expression in colon cancer and to analyze its clinical significance.Methods:The study detected FBXL5 expression in 60 colon cancer samples and 20 adjacent normal tissues by immunohistochemistry and analyzed the correlation between FBXL5 expression and clinicopathologic features and prognosis.Results:The positive rate of FBXL5 was markedly higher in colon cancer tissues［83.3%（50/60）］,more than adjacent normal tissues［25.0%（5/20）］.FBXL5 expression was significantly related with lymph node metastasis（P=0.027）and TNM stage(P=0.013).The expression of FBXL5 was correlated with patient survival(P=0.016).Multivariate analysis revealed that TNM stage was independent prognostic predictor for colon cancer.Conclusion:High expression of FBXL5 can promote the occurrence,development,invasion and metastasis of colon cancer,is expected to become the new direction for colon cancer treatment and judging prognosis effectively.

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黑龙江省教育厅科学技术研究项目（编号：12531664）
Last Update: 1900-01-01