|Table of Contents|

Relationship between expression of HER-2,PCNA,E-cadherin and clinical pathological parameters and prognosis in breast carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 18
Page:
2929-2934
Research Field:
Publishing date:

Info

Title:
Relationship between expression of HER-2,PCNA,E-cadherin and clinical pathological parameters and prognosis in breast carcinoma
Author(s):
Xie Lili1; Wang Donglin2
1.Basic Medicine Staff Room,Nantong Higher Vocational and Technical School of Health,Jiangsu Nantong 226007,China;2.Pathological Staff Room,Medical School of Nantong University，Jiangsu Nantong 226007，China.
Keywords:
breast carcinoma; HER-2; PCNA; E-cadherin; prognosis
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.18.019
Abstract:
Objective:To discuss the expression of HER-2,PCNA and E-cadherin and the relationship with clinical pathological parameters in breast carcinoma and their correlation with prognosis.Methods:With SP immunohistochemistry,the expression of HER-2,PCNA and E-cadherin was evaluated in 70 samples with invasive breast carcinoma,and 10 samples with breast fibroadenoma.Results:The high expression rates of HER-2,PCNA and E-cadherin in breast carcinoma were 58.57%,64.29% and 40.00% respectively,which were significantly different with that in breast fibroadenoma(P＜0.01).The expression of both of them in breast carcinoma had close correlation with the clinical TNM stage,histological grade,lymph node metastasis(P＜0.05),but the expression of HER-2 also had close correlation with ER(P＜0.05),and the expression of E-cadherin also had close correlation with tumor size(P＜0.05).Kaplan-Meier survival curve showed that patients with higher expression of HER-2 and PCNA,more number of lymph node metastasis and higher clinical TNM stage were worse than the corresponding ones,with significant differences(P＜0.01).Cox multivariate regression analysis showed that HER-2 and clinical TNM stage both could be independent prognostic indicators in breast carcinoma(P＜0.05).Conclusion:The up-regulated expression of HER-2 and PCNA as well as deletion of E-cadherin are involved in progression,metastasis and invasion of breast carcinoma and indicate poor prognosis.Combined detection of HER-2,PCNA and E-cadherin would be helpful in screening the patients with high risks of recurrence and metastasis,thus can be good for further treatment.

References:

［1］ Weng MX,Wu CH,Yang XP.Expression and significance of E-cadherin，CD44v6，and proliferating cell nuclear antigen in non-small cell lung cancer ［J］.Chin J Cancer,2008,27(2):191-195.［翁密霞，吴翠环，杨秀萍.E-cadherin,CD44v6和PCNA在非小细胞肺癌组织中的表达及意义［J］.癌症,2008,27(2):191-195.］
[2] Vesuna F,van Diest P,Chen JH,et al.Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer［J］.Biochem Biophys Res Commun,2008,367(2):235-241.
[3] Thomas Worzfeld,Jakub M Swiercz,Looso M,et al.ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis［J］.J Clin Invest,2012,122(4):1296-1305.
[4] Michael J Campbell,Denise Wolf,Mukhtar RA,et al.The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context［J］.PLoS One,2013,8(10):e79114.
[5] Chu-An Wang,David Drasin,Catherine Pham,et al.Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression［J］.Cancer Res,2014,74(24):7357-7370.
[6]Schmalhofer O,Brabletz S,Brabletz T.E-cadherin,beta-catenin,and ZEB1 in malignant progression of cancer［J］.Cancer Metastasis Rev,2009,28:151-166.
[7] Wan GX.The expression of HER-2/neu in human bladder carcinoma and siRNA effect on biological behavior of bladder cancer cell［D］.Changsha:Central South University,2008.［万光霞.HER-2/neu在人膀肤癌组织的表达及其siRNA对膀肤癌细胞生物学行为的影响［D］.长沙：中南大学，2008.］
[8] Tang YF,Xie LL.The relationships between expression of E-cadherin,BCA-225 and prognosis in breast cancer［J］.China Foreign Med Treat,2011,30（35）:20-23.［汤永峰，谢莉莉.乳腺癌中E-cadherin和BCA-225蛋白表达与预后的相关性研究［J］.中外医疗，2011，30（35）：20-23.］
[9]Qian JF,Yang QC,Xie HJ,et al.Relation between epithelial mesenchymal transition related proteins expressions and clinicopathologic features or prognosis of patients with invasive ductal carcinoma of breast［J］.Chin J Bases Clin General Surg,2015,22(5):591-596.［钱金锋，杨其昌，谢慧君，等.乳腺浸润性导管癌中上皮间质转化相关蛋白表达与临床病理特征和预后的关系［J］.中国普外基础与临床杂志，2015，22(5)：591-596.］
[10] Kuo-Shyang Jeng,I-Shyan Sheen,Wen-Juei Jeng,et al.High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma［J］.Onco Targets Ther,2014,7:79-86.
[11] Mahler M,Miyachi K,Peebles C,et al.The clinical significance of autoantibodies to the proliferating cell nuclear antigen(PCNA) ［J］.Autoimmun Rev,2012,11(10):771-775.

Memo

Memo:
-
Last Update: 1900-01-01