|Table of Contents|

Comparison of efficacy between thoracoscopic surgery and thoracotomy and effects on serum NSE,CA125 and EGF for large cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 18
Page:
2925-2929
Research Field:
Publishing date:

Info

Title:
Comparison of efficacy between thoracoscopic surgery and thoracotomy and effects on serum NSE,CA125 and EGF for large cell lung cancer
Author(s):
Ke Changkang; Lv Feng; Kang Shuhong; Bai Junfeng; Ni Yunfeng
Department of Thoracic Surgery,Tangdu Hospital,the Fourth Military Medical University,Shaanxi Xi'an 710038,China.
Keywords:
thoracoscopic surgery; thoracotomy; large cell lung cancer; NSE; CA125; EGF
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.18.018
Abstract:
Objective:To compare efficacy between thoracoscopic surgery and thoracotomy and investigate their effects on serum levels of neuron specific enolase(NSE),cancer antigen 125(CA125)and epidermal growth factor(EGF)for large cell lung cancer patients(LCLC).Methods:133 cases of LCLC received thoracoscopic surgery(TS)and thoracotomy(TC)were retrospectively analyzed.The surgical status,efficacy,complications and the levels of NSE,CA125 and EGF were compared.Results:The surgical time,bleeding volume,drainage tube placement time,visual analogue scale 5 days after operation and hospital stay in TS group were all significantly less than those in the TC group.But the cost of TS group was significantly more than TC group(P＜0.05).All the lesions were complete resection.Auxiliary lymph node dissection status and survival rate in 2 years had no significant difference between 2 groups(P＞0.05).TS group had significantly lower complication rate than TC group(P＜0.05).Serum levels of NSE,CA125 and EGF were all significantly reduced in d7 after surgery compared with in d1 before surgery.EGF level of TS group was significantly lower than that of TC group in d7 after surgery(P＜0.05).Conclusion:TS and TC are both efficient for LCLC patients,but TS patients have lower complication rate,smaller trauma and faster recurrence,and lower level of EGF.TS is worthy of promoting application for LCLC patients meeting the surgery indications.

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