|Table of Contents|

The expression and significance of PI3K and Ezrin in colorectal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 04
Page:
578-581
Research Field:
Publishing date:

Info

Title:
The expression and significance of PI3K and Ezrin in colorectal carcinoma
Author(s):
Li HongweiWang TieshanHuang YongLi WeiHu HaixiaXiong Zhengwen
Department of Pathology,the 251st Hospital of PLA,Hebei Zhangjiakou 075000,China.
Keywords:
colorectal adenocarcinomaPI3KEzrinimmunohistochemstrylightwave/microwave
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2017.04.020
Abstract:
Objective:To investigate the expression of PI3K and Ezrin in colorectal adenocarcinoma,and their features and clinical significance.Methods:The expression of PI3K and Ezrin was detected in 100 cases of colorectal adenocarcinoma and 30 cases of normal mucosa tissue by MW-EliVisionTM immunohistochemistry,and analyzed the relation between the expression and colorectal adenocarcinoma.Results:There was statistic signigicance in the expression of PI3K and Ezrin in normal mucosa and colorectal adenocarcinoma(P<0.05).The high expression of PI3K was apparently correlated to TNM stage,serous membrane invasion and lymph node metastasis(P<0.05).The expression of PI3K was not related to the expression of Ezrin(r=0.06,P>0.05).Conclusion:PI3K and Ezrin might play important roles in the development,invasion and metastasis of colorectal adenocarcinoma,which provided important imformation in clinical therapy and predicting prognosis of colorectal adenocarcinoma.

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Last Update: 2016-12-29