|Table of Contents|

Significance of MTDH expression in molecular subtypes of invasive breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 04
Page:
574-578
Research Field:
Publishing date:

Info

Title:
Significance of MTDH expression in molecular subtypes of invasive breast cancer
Author(s):
Liu Yan1Chen Chen2Lin Min2Li Baojiang1
1.Department of Breast Surgery;2.Department of Pathology,Tai'an Central Hospital,Shandong Tai'an 271000,China.
Keywords:
MTDHKi67breast cancerinvasive ductal carcinomamolecular subtype
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.04.019
Abstract:
Objective:To examine MTDH expression in different molecular subtypes of invasive breast cancer and to investigate the correlation with clinicopathological parameters.Methods:Pathological specimens from 287 patients with invasive ductal carcinoma of breast cancer were examined by immunohistochemistry for ER,PR,Ki67,HER-2 and MTDH expression.Correlations between the expression of MTDH and various clinicopathological factors were analyzed.Results:The positive rate of MTDH was 45.99% in all invasive breast cancer patients.MTDH expression was correlated with tumor size,lymphatic venous invasion,lymph nodal metastasis and TNM stage.However,there was no statistical difference of MTDH expression in molecular subtypes of invasive ductal carcinoma.The rate of MTDH was highest in Basal-like subtype,it was 55.32%.Conclusion:MTDH expression was significantly in Basal-like subtype,MTDH perhaps was a novel target gene in therapy of Basal-like subtype which was not sensitive to endocrinetherapy and trastuzumab.

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Last Update: 2016-12-29