|Table of Contents|

The expression and significance of kinesin Eg5 in non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 04
Page:
558-561
Research Field:
Publishing date:

Info

Title:
The expression and significance of kinesin Eg5 in non-small cell lung cancer
Author(s):
Yuan YanlongZhao JingyaSun YingWang JingSong XiaomingGuo Weidong
Department of Pathology,Handan Central Hospital,Hebei Handan 056001,China.
Keywords:
kinesinEg5non-small cell lung cancermetastasis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.04.015
Abstract:
Objective:To investigate the expression level of kinesin Eg5 in non-small cell lung cancer(NSCLC),and to explore its relation with metastasis of non-small cell lung cancer.Methods:To select 63 cases with non-small cell lung cancer surgical resection specimens and 20 cases of normal lung tissue samples,Eg5 expression was detected by immunohistochemistry,and its relation with clinical pathological features and metastasis of non-small cell lung cancer was analysed.Results:Immunohistochemistry showed Eg5 in normal lung tissue was not-obviously expressed,in non-small cell lung cancer overall expression positive rate was 68.3%(43/63),which was obviously related to the tumor diameter(χ2=4.506,P=0.034),clinical stage(χ2=8.866,P=0.012),lymph node metastasis(χ2=19.52,P<0.001),and the difference was statistically significant.There was no significant correlation with gender,age,degree of differentiation,and other indicators(P>0.05).Conclusion:Eg5 in normal lung tissue,there was no obvious expression while there was high expression in non-small cell lung cancer which was closely related to its clinical stage and metastasis.Eg5 can predict the lymph node metastasis of non-small cell lung cancer and may be a potential target in its therapeutics.

References:

[1]Liu YJ,Yang CC.The fashion trend of lung cancer and the burden of disease in China[J].Modern Trade and Industry,2016,2:212-213.[刘永军,杨婵婵.我国肺癌流行趋势及疾病负担概况[J].现代商贸工业,2016,2:212-213.]
[2]Li A,Niu FY,Han JF,et al.Predictive and prognostic value of de novo MET expression in patients with advanced non-small-celllung cancer[J].Lung Cancer,2015,90(3):375-380.
[3]Lu ZL,Ren WH,Jia WD,et al.The expression and significance of kinesin Eg5 in hepatocellular carcinoma [J].J Med University of Anhui,2012,47(9):28-30.[卢正磊,任维华,荚卫东,等.驱动蛋白 Eg5 在肝细胞癌中的表达及其意义[J].安徽医科大学学报,2012,47(9):28-30.]
[4]Le Guellec R,Paris JF,Coutrier A,et al.Clonning by differential screening of a xenopus CDNA that encodes a kinesin-related proteint [J].Mol Cell Biol,1991,11(6):3395-3398.
[5]Kwok BH,Yang JG,Kapoor TM,et al.The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5[J].Curr Biol,2004,14(19):1783-1789.
[6]Castillo A,Justice MJ.The kinesin related motor protein,Eg5,is essential for maintenance of pre-implantation embryogenesis[J].Biochem Biophys Res Commun,2007,357(3):694-699.
[7]Castillo A,Morse HC,Godfrey VL,et al.Overexpression of Eg5 causes genomic instability and tumor formation in mice[J].Cancer Res,2007,67(21):10138-10147.
[8]Liu L,Liu X,Mare M,et al.Overexpression of Eg5 correlates with high grade astrocytic neoplasm[J].J Neuro Oncol,2016,126(1):77-80.
[9]Nowicki MO,Pawlowski P,Fischer T,et al.Chronic myelogenous leukemia molecular signature[J].Oncogene,2003,22(25):3952-3963.
[10]Sun D,Lu J,Ding K,et al.The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma[J].Med Oncol,2013,30(1):476.
[11]Chen JX.Expression of Eg5 and PCNA in human bladder carcinoma and its influence on the biological behavior of bladder cancer [J].J Med University of Anhui,2014,06(8):743-753.[陈杰勋.Eg5、PCNA在人膀胱癌组织的表达及其对膀胱癌组织生物学行为的影响[J].安徽医科大学学报,2014,06(8):743-753.]
[12]Sun L,Lu J,Niu Z.A potent chemotherapeutic strategy with Eg5 inhibitor against gemcitabine resistant bladder cancer[J].PLoS One,2015,10(12):0144484.
[13]Saijo T,Ishii G,Ochiai A,et al. Eg5 expression is closely correla ted with the response of advanced non-small cell lung cancer to an-timitotic agents combined with platinum chemotherapy[J].Lung Cancer,2006,54(2):217-225.
[14]Liu X,Gong H,Huang K.Oncogenic role of kinesin proteins and targeting kinesin therapy[J].Cancer Sci,2013,104(6):651-656.
[15]Luo XY,Zhang M,Liu J.Progress of kinesin Eg5 inhibitors in cancer research[J].Chongqing Med J,2013,42(26):3172-3174.[罗兴燕,张梅,刘进.驱动蛋白Eg5抑制剂在肿瘤研究中的进展[J].重庆医学,2013,42(26):3172-3174.]

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Last Update: 2016-12-29