|Table of Contents|

Progress in the relationship between chromatin helicase DNA binding protein and tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
992-995
Research Field:
Publishing date:

Info

Title:
Progress in the relationship between chromatin helicase DNA binding protein and tumor
Author(s):
Wang XueYang LianheYu JianfaShen ShuaiYu ChengqianLan QiLi Zhengye
China Medical University,Liaoning Shenyang 110000,China.
Keywords:
CHD5hypermethylationtumortumor suppressor gene
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2016.06.043
Abstract:
Chromatin helicase DNA binding protein 5 (CHD5) belongs to chromatin remodeling enzymes,which can not only promote gene transcription because of chromatin remodeling,but also upregulate p53/p19arf when controlling cell proliferation,apoptosis and senescence.At present,CHD5 missing has been found in various kinds of tumors like neuroblastoma,glioma,breast cancer and lung cancer and scientists also find that the low expression is related to tumor occurrence,development and prognosis.In a variety of tumors,CHD5 gene deletion occurs single or double stranded,as well as hypermethylation,leading to down regulation.Hence,CHD5 plays an important role in the development of tumor both by genetic and epigenetic mechanisms of joint control in tumor progression.

References:

[1]Marfella CG,Imbalzano AN.The Chd family of chromatin remodelers[J].Mutat Res,2007,618(1-2):30-40.
[2]Wang HP,Xu QZ,Zhou PK.Progress on chromatin remodeling factor CHD[J].Int J Radiation Med Nuclear Med,2006,30(1):42-43.[王会平,徐勤枝,周平坤.染色质重构因子CHD蛋白家族的研究进展[J].国际放射医学核医学杂志,2006,30(1):42-43.]
[3]Oliver SS,Musselman CA,Srinivasan R,et al.Multivalent recognition of histone tails by the PHD fingers of CHD5[J].Biochemistry,2012,51(33):6534-6544.
[4]Paul S,Kuo A,Schalch T,et al.Chd5 requires PHD-mediated histone 3 binding for tumor suppression[J].Cell Rep,2013,3(1):92-102.
[5]Egan CM,Nyman U,Skotte J,et al.CHD5 is required for neurogenesis and has a dual role in facilitating gene xpression and polycomb gene repression[J].Dev Cell,2013,26(3):223-236.
[6]Thompson PM,Gotoh T,Kok M,et al.CHD5,a new member of the chromodomain gene family,is preferentially expressedin the nervous system[J].Oncogene,2003,22(7):1002-1011.
[7]Kolla V,Naraparaju K,Zhuang T,et al.The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex[J].Biochem J,2015,468(2):345-352.
[8]Bagchi A,Papazoglu C,Wu Y,et al.CHD5 is a tumor suppressor at human 1p36[J].Cell,2007,128(3):459-475.
[9]Brodeur GM.Neuroblastoma:biological insights into a clinical enigma[J].Nat Rev Cancer,2003,3(3):203-216.
[10]Brodeur GM,Hogarty MD,Mosse YP,et al.Neuroblastoma[A].Pizzo PA,Poplack DG.Principles and practice of pediatric oncology[M].Philadelphia,PA:Lippincott,Williams and Wilkins,2011:886-922.
[11]Brodeur GM,Sekhon G,Goldstein MN.Chromosomal aberrations in human neuroblastomas[J].Cancer,1977,40(5):2256-2263.
[12]Attiyeh EF,London WB,Mosse YP,et al.Chromosome 1p and 11q deletions and outcome in neuroblastoma[J].N Engl J Med,2005,353:2243-2253.
[13]Brodeur GM,Green AA,Hayes FA,et al.Cytogenetic features of human neuroblastomas and cell lines[J].Cancer Res,1981,41(11):4678-4686.
[14]Fong CT,Dracopoli NC,White PS,et al.Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas:correlation with N-myc amplification[J].Proc Natl Acad Sci USA,1989,86(10):3753-3757.
[15]Maris JM,White PS,Beltinger CP,et al.Significance of chromosome 1p loss of heterozygosity in neuroblastoma[J].Cancer Res,1995,55(20):4664-4669.
[16]White PS,Maris JM,Beltinger C,et al.A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3[J].Proc Natl Acad Sci USA,1995,92(12):5520-5524.
[17]White PS,Thompson PM,Gotoh T,et al.Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma[J].Oncogene,2005,24(16):2684-2694.
[18]Fujita T,Igarashi J,Okawa ER,et al.CHD5,a tumor suppressor gene deleted from 1p36.31 in neuroblastomas[J].J Natl Cancer Inst,2008,100(13):940-949.
[19]Garcia I,Mayol G,Rodriguez E,et al.Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma[J].Mol Cancer,2010,9:277.
[20]Koyama H,Zhuang T,Light JE,et al.Mechanisms of CHD5 Inactivation in neuroblastomas[J].Clin Cancer Res,2012,18(6):1588-1597.
[21]Okawa ER,Gotoh T,Manne J,et al.Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas[J].Oncogene,2008,27(6):803-810.
[22]Li H,Xu W,Huang Y,et al.Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo[J].Int J Mol Med,2012,30(5):1081-1086.
[23]Bagchi A,Papazoglu C,Wu Y,et al.CHD5 is a tumor suppressor at human 1p36[J].Cell,2007,128(3):459-475.
[24]Law ME,Templeton KL,Kitange G,et al.Molecular cytogenetic analysis of chromosomes 1 and 19 in glioma cell lines[J].Cancer Genet Cytogenet,2005,160(1):1-14.
[25]Wang L,He S,Tu Y,et al.Downregulation of chromatin remodeling factor CHD5 is associated with a poor prognosis in human glioma[J].J Clin Neurosci,2013,20(7):958-963.
[26]Sonia Mulero-Navarro,Manel Esteller.Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer[J].J Epigenetics,2008,3(4):210-215.
[27]Han LL,Hou L,Song JL.Genetic polymorphisms of methionine synthase,methylation of CHD5,and their association with breast cancer mobidity[J].China Oncol,2010,20(4):251-255.[韩琳琳,侯琳,宋金莲.甲硫氨酸合成酶多态性及CHD5基因甲基化与乳腺癌发病的关系[J].中国癌症杂志,2010,20(4):251-255.]
[28]Wu X,Zhu Z,Li W,et al.Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer[J].Breast Cancer Res,2012,14(3):R73.
[29]Zhao R,Yan Q,Lv J,et al.CHD5,a tumor suppressor that is epigenetically silenced in lung cancer[J].Lung Cancer,2012,76(3):324-331.
[30]Mokarram P,Kumar K,Brim H,et al.Distinct high-profile methylated genes in colorectalcancer[J].PLoS One,2009,4(9):e7012.
[31]Fatemi M,Paul TA,Brodeur GM,et al.Epigenetic silencing of CHD5,a novel tumor-suppressor gene,occurs in early colorectal cancer stages[J].Cancer,2014,120(2):172-180.
[32]Cai C,Ashktorab H,Pang X,et al.MicroRNA-211 expressionpromotes colorectal cancer cell growthin vitro and in vivo by targeting tumor suppressor CHD5[J].PLoS One,2012,7(1):e29750.
[33]Zhao R,Wang NS,Huang HL,et al.CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma[J].Liver International,2014,34:151-160.
[34]Yu L,Gong X,Sun L,et al.miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma[J].Oncotarget,2015,7:30.
[35]Wang J,Chen H,Fu S,et al.The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma[J].Oral Oncol,2011,47(7):601-108.
[36]He QY.Study on epigenetic change of CHD5 gene in esophageal cancer[D].Zheng Zhou:The First Affiliated Hospital of Zhengzhou University,2012:1-47.[何巧玉.食管癌中CHD5基因表观遗传学改变[D].郑州:郑州大学第一附属医院,2012:1-47.]
[37]Wang X,Lau KK,So LK,et al.CHD5 is down-regulated through promoter hypermethylation in gastric cancer[J].J Biomed Sci,2009,16:95.
[38]Qu Y,Dang S,Hou P.Gene methylation in gastric cancer[J].Clin Chim Acta,2013,424:53-65.
[39]Gorringe KL,Choong DY,Williams LH,et al.Mutation and methylation analysis of the chromodomainhelicase-DNA binding 5 gene in ovarian cancer[J].Neoplasia,2008,10(11):1253-1258.
[40]Wong RR,Chan LK,Tsang TP,et al.CHD5 downregulation associated with poor prognosis in epithelial ovarian cancer[J].Gynecol Obstet Invest,2011,72(3):203-207.
[41]Zhang Y,Luo ZQ,Du XJ,et al.The relationship between the clinical significance and prognosis of XAF1 CHD5 express deliver convey show communicate and Ki67 in tumor of ovary serous adenocarcinoma[J].China & Foreign Med Treat,2013,06(a):38-39.[张燕,罗政权,杜秀杰,等.XAF1、CHD5和Ki67在卵巢肿瘤浆液性腺癌中表达的临床意义及与预后的关系[J].中外医疗,2013,06(a):38-39.]
[42]Du X,Wu T,Lu J,et al.Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma[J].Clin Transl Oncol,2013,15(3):198-204.
[43]Hall WA,Petrova AV,Colbert LE,et al.Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer[J].Oncogene,2014,33(47):5450-5456.

Memo

Memo:
国家自然科学基金项目(编号:81301930);辽宁省教育厅科学研究一般项目(编号:L2015595)
Last Update: 2016-01-29