|Table of Contents|

The mainly intracellular signaling pathways of leptin in the colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
984-988
Research Field:
Publishing date:

Info

Title:
The mainly intracellular signaling pathways of leptin in the colorectal cancer
Author(s):
Zhao Shuangshuang1; 2; Xu Qing1; 2
1.Department of Medical Oncology,Shanghai Tenth People's Hospital,Shanghai 200072,China;2.Tongji University,School of Medicine,Shanghai 200072,China.
Keywords:
leptin; leptin receptor; obesity; colorectal cancer
PACS:
R735.3+5;R735.3+7
DOI:
10.3969/j.issn.1672-4992.2016.06.041
Abstract:
Amounts of epidemiological evidence indicates that changing of lifestyle and resulting obesity are responsible for the synthesis and development of colorectal cancer(CRC).The obesity will increase the risk of colorectal cancer.Leptin that is synthesized and secreted by adipose tissue is a product of the obesity gene.So leptin is considered as an important link between obesity and colorectal cancer.Many researches found that leptin promoted CRC proliferation,inhibition of apoptosis,induction of tumor invasion and metastasis by activating multiple signaling pathways.This article is to review the studies of the mainly intracellular signaling pathways of leptin in the occurrence and development of colorectal cancer.

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Last Update: 2016-01-29