|Table of Contents|

Ras and TβRII expression in vulvar squamous cell carcinoma and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
974-977
Research Field:
Publishing date:

Info

Title:
Ras and TβRII expression in vulvar squamous cell carcinoma and its clinical significance
Author(s):
Wang Yanshi; Li Hui; Ren Lina; Chen Xue; Wu Xin
Department of Gynecology，First Affiliated Hospital of China Medical University，Liaoning Shenyang 110001，China．
Keywords:
vulvar squamous cell carcinoma; Ras; TβRII; immunohistochemistry
PACS:
R737.35
DOI:
10.3969/j.issn.1672-4992.2016.06.038
Abstract:
Objective:To investigate the expression of Ras and TβRII in vulva squamous cell carcinoma(VSCC),and its association with occurrence and developmen of disease.Methods:Immunohistochemistry was conducted to detect the expression of Ras and TβRII in both VSCC (n=25)and normal vulva tissues(n=15),and analyzed the relationship between the expression of Ras，TβRII protein and clinical and pathological data of patients with VSCC.Results:The expression of Ras in VSCC was significantly higher than normal vulva skin tissue and the difference was statistically significant(P＜0.05).Ras expression in VSCC tissue of III stage was significantly higher than that of stage I-II(P＜0.05).The expression of Ras in cases with lymph node metastasis was higher than those without lymph node metastasis(P＜0.05).Ras expression had no statistically significant difference between the poorly and moderately differentiated VSCC and the highly differentiated ones(P＞0.05).The expression of TβRII in VSCC was significantly lower than normal vulva skin tissue(P＜0.05).TβRII expression in VSCC tissue of III stage was significantly lower than that of stage I-II(P＜0.05).The expression of TβRII in the moderately and poorly differentiated VSCC was lower than those well differentiated VSCC(P＜0.05).The expression of TβRII in cases with lymph node metastasis was lower than those without lymph node metastasis(P＜0.05).The Pearson correlation analysis showed that Ras and TβRII expression was negatively correlated in vulva squamous cell carcinoma.Conclusion:The expression of Ras and TβRII was associated with occurrence and development of VSCC.

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Memo

Memo:
国家自然科学基金(编号：30973190);辽宁省科学技术计划项目(编号：2014021057)
Last Update: 2016-01-29