|Table of Contents|

Interaction between selenium-deficient and GPX polymorphism in acute leukemia in Enshi population China

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
955-957
Research Field:
Publishing date:

Info

Title:
Interaction between selenium-deficient and GPX polymorphism in acute leukemia in Enshi population China
Author(s):
Li Yanbi; Liu Jingzhen
Department of Physical Neonate,The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Hubei Enshi 445000,China.
Keywords:
MTHFR; polymorphism; acute leukemia; susceptibility; interaction
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2016.06.032
Abstract:
Objective:To study the relationship between GPX1 pro200leu polymorphism in endothelial nitric oxide synthase and susceptibility to acute leukemia and their interaction with selenium-deficient in Enshi population.Methods:Genotypes of 121 patients with acute leukemia and 129 controls were examined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).The unconditional logistic regression (ULR) was performed to assess the acute leukemia risk and interaction with drinking.Results:That there was increased risk of developing acute Leukemia for LL/PL genotype carriers compared with PP (OR=11.44,95%CI:1.28~1.61,P=0.000;AdjustOR=1.53,95%CI:1.31~3.01,P=0.000).By using the ULR method,selenium-deficient-positive subjects with genotype PL/LL in have an acute Leukemia risk 3.39 times that of selenium-deficient-negative subjects with genotype PP(OR=3.39,95%CI:2.66~5.36,P=0.000)(RERI=1.83,95%CI:1.21~2.78;API=0.46,95%CI:0.28,0.76;S=1.31,95%CI:1.08~2.17).Conclusion:GPX1 pro200leu polymorphism was associated with increased risk of acute leukemia,and its interaction with selenium-deficient have synergistic effects on risk of acute leukemia in Enshi population.

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Memo

Memo:
湖北省自然科学基金(编号：2013DC128)
Last Update: 2016-01-29