|Table of Contents|

Clinical observation of pemetrexed combined with lobaplatin in the treatment of 92 cases of advanced lung adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2016 06
Page:
899-902
Research Field:
Publishing date:

Info

Title:
Clinical observation of pemetrexed combined with lobaplatin in the treatment of 92 cases of advanced lung adenocarcinoma
Author(s):
Gao Eryun1Li Min1Chen Liqiong1Han Xiaohu2
1.Department of Oncology;2.Department of Nephrology,Ma'anshan People's Hospital,Anhui Ma'anshan 243000,China.
Keywords:
pemetrexed combined lobaplatinadvanced lung adenocarcinomaclinical effectadverse events
PACS:
R730.53;R734.2
DOI:
10.3969/j.issn.1672-4992.2016.06.015
Abstract:
Objective:To observe the adverse events and clinical effects of pemetrexed combined with lobaplatin in the treatment of advanced lung adenocarcinoma.Methods:All 92 patients with advanced lung cancer who were treated in our hospital from January 2010 to September 2013 were selected,they were divided into study group (n=46) and control group (n=46).The study group were given pemetrexed combined lobaplatin treatment,while the control group were given pemetrexed plus cisplatin therapy.Results:The difference of RR 58.7%(27/46),54.3%(25/46) and DCR 93.5%(43/46),84.8%(39/46),MST,PFS and 1-year 2-year survival rates between the study group and the control group were not significant (P<0.05),the difference was not significant (P<0.05).Adverse reactions of nausea,vomiting,elevated creatinine significantly reduced of patients in the study group with clinically acceptable,thrombocytopenia significantly increased (P<0.05),after L-platelet therapy improved.The nausea,vomiting,elevated creatinine of the control group was significantly increased (P<0.05).Conclusion:Pemetrexed combined lobaplatin is more effective in reducing adverse reactions of patients in the treatment of advanced lung adenocarcinoma than pemetrexed combination with cisplatin,the clinical effect is undifferentiated.

References:

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Last Update: 2016-01-29