|Table of Contents|

Clinical study of induction chemotherapy plus concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2015 06
Page:
774-778
Research Field:
Publishing date:

Info

Title:
Clinical study of induction chemotherapy plus concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma
Author(s):
Li Zhuoling12Jin Feng12Wu Weili2Li Yuanyuan2Long Jinhua2Gong Xiuyun2Chen Xiaoxiao2Mao Zhenhua2Bi Ting2He Qianyong2Qu Bo2
1.Guiyang Medical University,Guizhou Guiyang 550004,China;2.Department of Oncology,Affiliated Hospital of Guiyang Medical College,Department of Head and Neck Oncology,Guizhou Cancer Hospital,Guizhou Guiyang 550004,China.
Keywords:
nasopharyngeal carcinomainduction chemotherapyconcurrent chemoradiotherapy
PACS:
R739.6
DOI:
10.3969/j.issn.1672-4992.2015.06.14
Abstract:
Objective:To evaluate the safety and chlinical response of induction chemotherapy plus concurrent chemotherapy with intensity-modulated radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma.Methods:All 26 patients were treated by induction chemotherapy plus concurrent chemotherapy with intensity-modulated radiotherapy.Induction chemotherapy with docetaxel and cisplatin and 5-fluorouracil(TPF),docetaxel 75mg/m2,infusion,d1;cisplatin 75mg/m2,infusion,d1;5-fluorouracil 750mg/(m2?d),continuous intravenous pumping,d1-5(120h);21 days/cycle,a total of two cycles.Concurrent chemotherapy with cisplatin,100mg/m2,infusion,d1;21 days/cycle,a total of two or three cycles.Concurrent radiotherapy GTVnx (69.96-73.92)Gy/33f,PTVnx 69.96Gy/33f,PGTVnd 69.96Gy/33f,PTV1 60.06Gy/33f,PTV2 50.96Gy/28f.Results:The main adverse reactions of induction chemotherapy were nausea and bone marrow suppression,the main adverse reactions of concurrent chemoradiotherapy included bone marrow suppression,oral mucositis,dermatitis.No adverse reactions related death.After concurrent chemoradiotherapy the complete response rate was 69.2%,partial response rate was 26.9%,stable disease rate was 3.8%,overall response rate was 96.1%.After 3 months of concurrent chemoradiotherapy the complete response rate was 84.6%,partial response was 11.5%,stable disease was 3.8%,overall response rate was 96.1%.Conclusion:Induction chemotherapy of TPF plus concurrent chemotherapy of cisplatin with intensity-modulated radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma is effective therapy,with acceptable adverse reactions.This is an acceptable and safe treatment.

References:

[1]杜清华,王仁生.局部晚期鼻咽癌诱导化疗的研究进展[J].广东医学,2012,33(17):2685-2688.
[2]李娜,孙凯,王英迪.中晚期鼻咽癌同步放化疗的近期疗效观察[J].中国医药指南,2012,10(30):534-535.
[3]Lee N,Harris J,Garden AS,et al.Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma:Radiation therapy oncology group phase II trial 0225[J].J Clin Oncol,2009,27(10):3684-3690.
[4]Airoldi M,Gabriele AM,Garzaro M,et al.Induction chemotherapy with cisplatin and epirubicin followed by radiotherapy and concurrent cisplatin in locally advanced nasopharyngeal carcinoma observed in a non-endemic population[J].Radiother Oncol,2009,92(1):105-110.
[5]Komatsu M,Tsukuda M,Matsuda H,et al.Comparison of concurrent chemoradiotherapy versus induction chemotherapy followed by radiation in patients with nasopharyngeal carcinoma[J].Anticancer Res,2012,32(2):681-686.
[6]Hui EP,Ma BB,Leung SF,et al.Randomized phase Ⅱ trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma[J].J Clin Oncol,2009,27(2):242-249.
[7]马静静,张云波,赵美红,等.TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效分析[J].安徽医药,2011,15(10):1291-1293.
[8]吴金通,彭俊英,吴陈宾,等.TPF方案诱导化疗对局部晚期鼻咽癌临床疗效的影响[J].实用癌症杂志,2014,29(2):143-145.
[9]李媛媛,金风,吴伟莉,等.时辰诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌的Ⅱ期临床研究[J].中国肿瘤临床,2013,40(15):914-918.
[10]Ekenel M,Keskin S,Basaran M,et al.Induction chemotherapy with docetaxel and cisplatin is highly effective for locally advanced nasopharyngeal carcinoma[J].Oral Oncol,2011,47(7):660-664.
[11]Chen SZ,Chen XM,Ding Y,et al.Combined chemotherapy with cisplatin,docetaxel and capecitabine for metastatic nasopharyngeal carcinoma:A retrospective analysis[J].Nan Fang Yi Ke Da Xue Xue Bao,2011,31(7):1114-1118.
[12]Lorch JH,Goloubeva O,Haddad RI,et al.Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck:Long-term results of the TAX 324 randomised phase 3 trial[J].Lancet Oncol,2011,12(2):153-159.
[13]林焕新,孙蕊,徐敏,等.TPF方案诱导化疗加同期顺铂化放疗治疗晚期鼻咽癌的临床研究[J].肿瘤研究与临床,2010,22(8):515-518.
[14]Bae WK,Hwang JE,Shim HJ,et al.PhaseⅡstudy of docetaxel,cisplatin,and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionaly advanced nasopharyngeal cancer[J].Cancer Chemother Pharmacol,2010,65(3):589-595.
[15]Bossi P,Orlandi E,Bergamini C,et al.Docetaxel,cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer[J].Ann Oncol,2011,22(11):2495-2500.
[16]Kong L,Zhang YW,Hu CS,et al.Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma[J].Chin J Cancer,2010,29(5):551-555.
[17]Lee AW,Lau WH,Tung SY,et al.Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally advanced nasopharyngeal carcinoma:NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group[J].J Clin Oncol,2005,23(28):6966-6975.
[18]Al-Amro A,Al-Rajhi N,Khafaga Y,et al.Neoadjuvant chemotherapy followed by concurrent chemoradiation therapy in locally advanced nasopharyngeal carcinoma[J].Int J Radiat 0ncol Biol Phys,2005,62(2):508-513.
[19]Wee J,Tan EH,Tai BC,et al.Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stageⅢ and Ⅳnasopharyngeal cancer of the endemic variety[J].J Clin Oncol,2005,23(27):6730-6738.

Memo

Memo:
贵州省科技厅社发攻关联合基金项目(编号:黔科合LG字【2012】065号);贵阳市社会发展与民生科技计划项目(编号:筑科合同【2013103】29号)
Last Update: 2015-02-02